Journal article
Effects of alfentanil and lidocaine on the hemodynamic responses to laryngoscopy and tracheal intubation
Journal of clinical anesthesia, Vol.2(2), pp.81-85
1990
DOI: 10.1016/0952-8180(90)90058-B
PMID: 2189452
Abstract
This study was undertaken to determine whether lidocaine and/or alfentanil can effectively abolish or attenuate the increase in mean arterial pressure (MAP), heart rate (HR), and rate pressure product (RPP) associated with rapid sequence induction of anesthesia. Sixty patients were randomly divided into four groups. Group 1 received saline 10 ml, group 2 received lidocaine 2 mg/kg, group 3 received alfentanil 15 μg/kg, and group 4 received alfentanil 30 μg/kg. All patients were induced with sodium thiopental 4 mg/kg and succinylcholine 1.5 mg/kg to facilitate tracheal intubation. The study drug was given after sodium thiopental was administered, and the investigator was blinded to it. Blood Pressure (BP) and HR were recorded at the following times: before induction; after induction but before laryngoscopy and intubation; and 1, 3, and 5 minutes after intubation. Alfentanil 15 and 30 μg/kg given in rapid sequence fashion with thiopental and succinylcholine effectively blunted the hemodynamic responses to laryngoscopy and tracheal intubation. Lidocaine 2 mg/kg and saline were found to be ineffective in blunting these same responses.
Details
- Title: Subtitle
- Effects of alfentanil and lidocaine on the hemodynamic responses to laryngoscopy and tracheal intubation
- Creators
- Dhirendra PathakRoger M SlaterSam S.T Sum PingRobert P From
- Resource Type
- Journal article
- Publication Details
- Journal of clinical anesthesia, Vol.2(2), pp.81-85
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0952-8180(90)90058-B
- PMID
- 2189452
- ISSN
- 0952-8180
- eISSN
- 1873-4529
- Language
- English
- Date published
- 1990
- Academic Unit
- Anesthesia
- Record Identifier
- 9984007179602771
Metrics
29 Record Views