Journal article
Effects of anxiety on the long-term course of depressive disorders
British journal of psychiatry, Vol.200(3), pp.210-215
03/2012
DOI: 10.1192/bjp.bp.110.081992
PMCID: PMC3290796
PMID: 21984801
Abstract
Background
It is well established that the presence of prominent anxiety within depressive episodes portends poorer outcomes. Important questions remain as to which anxiety features are important to outcome and how sustained their prognostic effects are over time.
Aims
To examine the relative prognostic importance of specific anxiety features and to determine whether their effects persist over decades and apply to both unipolar and bipolar conditions.
Method
Participants with unipolar (n = 476) or bipolar (n = 335) depressive disorders were intensively followed for a mean of 16.7 years (s.d. = 8.5).
Results
The number and severity of anxiety symptoms, but not the presence of pre-existing anxiety disorders, showed a robust and continuous relationship to the subsequent time spent in depressive episodes in both unipolar and bipolar depressive disorder. The strength of this relationship changed little over five successive 5-year periods.
Conclusions
The severity of current anxiety symptoms within depressive episodes correlates strongly with the persistence of subsequent depressive symptoms and this relationship is stable over decades.
Details
- Title: Subtitle
- Effects of anxiety on the long-term course of depressive disorders
- Creators
- William Coryell - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa and Department of Psychiatry, Columbia University College of Physicians and Surgeons, New YorkJess G Fiedorowicz - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Hospitals and Clinics, IowaDavid Solomon - Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode IslandAndrew C Leon - Department of Psychiatry, Columbia University College of Physicians and Surgeons, New YorkJohn P Rice - Department of Psychiatry, Washington University School of Medicine, St Louis, MissouriMartin B Keller - Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
- Resource Type
- Journal article
- Publication Details
- British journal of psychiatry, Vol.200(3), pp.210-215
- Publisher
- Cambridge University Press; Cambridge, UK
- DOI
- 10.1192/bjp.bp.110.081992
- PMID
- 21984801
- PMCID
- PMC3290796
- ISSN
- 0007-1250
- eISSN
- 1472-1465
- Number of pages
- 6
- Language
- English
- Date published
- 03/2012
- Academic Unit
- Psychiatry; Epidemiology; Internal Medicine
- Record Identifier
- 9984003420302771
Metrics
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