Journal article
Effects of atrial fibrillation on outcomes of influenza hospitalization
International journal of cardiology. Heart & vasculature, Vol.42, pp.101106-101106
10/01/2022
DOI: 10.1016/j.ijcha.2022.101106
PMCID: PMC9403342
PMID: 36032267
Abstract
Background: There is little information available on AF and its association with outcomes in adult influenza hospitalizations.Methods: The National Inpatient Sample was queried from years 2009-2018 to create a cohort of discharges containing an influenza diagnosis. AF was the primary exposure. Univariate and multivariate regression analysis was used to describe the association of AF with clinical and healthcare-resource outcomes. Finally, a doubly-robust analysis using average treatment effect on the treated (ATT) propensity score weighting was performed to verify the results of traditional regression analysis.Results: After adjustment, the presence of AF during influenza hospitalization was associated with higher odds of in-hospital mortality (aOR 1.56, 95 % CI 1.49 - 1.65), acute respiratory failure (aOR 1.22, 95 % CI 1.19 - 1.25), acute respiratory failure with mechanical ventilation (aOR 1.37, 95 % CI 1.32 - 1.41), acute kidney injury (aOR 1.09, 95 % CI 1.06 - 1.12), acute kidney injury requiring dialysis (aOR 1.61, 95 % CI 1.46 - 1.78) and cardiogenic shock (aOR 1.90, 95 % CI 1.65 - 2.20, all p-values < 0.0001). These findings were validated in our propensity score analysis using ATT weights. The presence of AF was also associated with higher total charges and costs of hospitalization, as well as a significantly longer length of stay (all p-values < 0.0001).Conclusion: AF is a cardiovascular comorbidity associated with worse clinical and healthcare resource outcomes in influenza requiring hospitalization. Its presence should be used to identify patients with influenza at risk of worse prognosis.
Details
- Title: Subtitle
- Effects of atrial fibrillation on outcomes of influenza hospitalization
- Creators
- Alexander Bolton - University of IowaHarshith Thyagaturu - Bassett Medical CenterMuddasir Ashraf - University of IowaRyan Carnahan - Univ Iowa, Coll Publ Hlth, Iowa City, IA USADenice Hodgson-Zingman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- International journal of cardiology. Heart & vasculature, Vol.42, pp.101106-101106
- DOI
- 10.1016/j.ijcha.2022.101106
- PMID
- 36032267
- PMCID
- PMC9403342
- NLM abbreviation
- Int J Cardiol Heart Vasc
- ISSN
- 2352-9067
- eISSN
- 2352-9067
- Publisher
- Elsevier
- Number of pages
- 7
- Language
- English
- Date published
- 10/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Epidemiology; Cardiovascular Medicine; Nursing; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984359693602771
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