Journal article
Effects of benzo(a)pyrene, 3,3′,4,4′-tetrachlorobiphenyl and 2,2′,4,4′,5,5′-hexachlorobiphenyl on the xenobiotic-metabolizing enzymes in the mussel ( Mytilus galloprovincialis)
Aquatic toxicology, Vol.27(3), pp.335-344
1993
DOI: 10.1016/0166-445X(93)90062-6
Abstract
Benzo(a)pyrene (BaP), 3,3′,4,4′-tetrachlorobiphenyl (TCB) and 2,2′,4,4′,5,5′-hexachlorobiphenyl were tested for their ability to induce hepatic xenobiotic metabolizing enzymes in a marine mussel. TCB and BaP (two planar molecules), but not HCB (a bulky PCB), increased phase I enzyme parameters including the P-450 content, NADPH cytochrome
c reductase activity and BaP oxidase activity. The glutathione
S-transferase activity and glutathione content increased in HCB-treated mussels and decreased or remained the same as in the control in BaP- and TCB-exposed animals. Epoxide hydrolase (EH) activity increased in BaP- and HCB- but not in TCB-treated groups. These results show that, as in fish, only 3-methylcholanthrene P-450-type inducers (BaP and TCB, a non-
ortho-substituted PCB) and not the phenobarbital P-450-type inducer (HCB, a di-
ortho-substituted PCB) are effective inducers of phase I enzymes in mussel at the doses tested. Phase II activities were more sensitive to BaP and HCB than to TCB treatment.
Details
- Title: Subtitle
- Effects of benzo(a)pyrene, 3,3′,4,4′-tetrachlorobiphenyl and 2,2′,4,4′,5,5′-hexachlorobiphenyl on the xenobiotic-metabolizing enzymes in the mussel ( Mytilus galloprovincialis)
- Creators
- X.R. Michel - University of BordeauxP. Suteau - University of BordeauxL.W. Robertson - University of KentuckyJ.-F. Narbonne - University of Bordeaux
- Resource Type
- Journal article
- Publication Details
- Aquatic toxicology, Vol.27(3), pp.335-344
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0166-445X(93)90062-6
- ISSN
- 0166-445X
- eISSN
- 1879-1514
- Language
- English
- Date published
- 1993
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984363595302771
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