Journal article
Effects of central and intravascular angiotensin I and II on the choroid plexus
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.261(5), pp.R1126-R1132
11/01/1991
DOI: 10.1152/ajpregu.1991.261.5.R1126
PMID: 1951760
Abstract
The choroid plexus contains receptors for angiotensin II (ANG II) and a very high concentration of angiotensin-converting enzyme. The goal of this study was to test the hypothesis that central, as well as circulating, ANG I and II decrease blood flow to the choroid plexus. Under control conditions in anesthetized rabbits, blood flow (microspheres) to the choroid plexus was 449 +/- 21 (mean +/- SE) ml.min-1.100 g(-1). Intravascular ANG I (30 and 100 ng.kg-1.min-1) decreased blood flow to the choroid plexus by 19 +/- 14 and 28 +/- 18%, respectively. Intravascular ANG II (30 and 100 ng.kg-1.min-1) also produced a decrease in blood flow by 28 +/- 9 and 47 +/- 7%, respectively. When administered into the lateral ventricle, ANG I and II (10 and 100 ng.kg-1.min-1) decreased blood flow to a similar degree: 22 +/- 11 and 31 +/- 10% and 12 +/- 10 and 27 +/- 8%, respectively. Cerebral blood flow was not decreased by intravascular or central ANG I or II. The angiotensin-converting enzyme inhibitor quinaprilat prevented the decrease in blood flow to the choroid plexus in response to ANG I without affecting responses to ANG II. Thus 1) circulating ANG I and II are potent constrictors of blood vessels of the choroid plexus, 2) the constrictor effect of ANG I on the blood vessels of the choroid plexus appears mediated primarily by generation of ANG II, and 3) intracerebroventricular ANG I produces large reductions in the blood flow to the choroid plexus, which suggests that there is an effective central system that converts ANG I to ANG II.
Details
- Title: Subtitle
- Effects of central and intravascular angiotensin I and II on the choroid plexus
- Creators
- M. A Maktabi - Department of Anesthesia, University of Iowa College of Medicine, IowaCity 52242D. D Heistad - Department of Anesthesia, University of Iowa College of Medicine, IowaCity 52242F. M Faraci - Department of Anesthesia, University of Iowa College of Medicine, IowaCity 52242
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.261(5), pp.R1126-R1132
- DOI
- 10.1152/ajpregu.1991.261.5.R1126
- PMID
- 1951760
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 11/01/1991
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040322102771
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