Journal article
Effects of chronic beta-adrenergic blockade on exercise training in dogs
Journal of applied physiology (1985), Vol.64(5), pp.1960-1967
05/01/1988
DOI: 10.1152/jappl.1988.64.5.1960
PMID: 3391896
Abstract
To assess the role of beta-adrenergic stimulation in cardiovascular conditioning we examined the effects of a beta-adrenergic blocker, propranolol, in mongrel dogs during an 8-wk treadmill-training program. Seven dogs were trained without a drug (NP), six were trained on propranolol 10 mg.kg-1.day-1 (P), and five served as caged controls (C). Effective beta-adrenergic blockade was documented by a decrease in peak exercise heart rate of 54 +/- 11 (SE) beats/min (P less than 0.05) and a one-log magnitude of increase in the isoproterenol-heart rate dose-response curve. Testing was performed before drug treatment or training and again after training without the drug for 5 days. Submaximal exercise heart rate decreased similarly in both NP and P (-26 +/- 4 NP vs. -25 +/- 9 beats/min P, P less than 0.05 for both) but peak heart rate decreased only with NP (-33 +/- 9 beats/min, P less than 0.05). Treadmill exercise time increased similarly in both groups: 3.4 +/- 0.6 min in NP and 3.0 +/- 0.2 min in P (both P less than 0.05). Blood volume also increased after training in both groups: 605 +/- 250 ml (26%) in NP and 377 +/- 140 ml (17%) in P (both P less than 0.05). Submaximal exercise arterial lactates were reduced similarly in both groups but peak exercise lactate was reduced more in NP (-1.4 +/- 0.3 NP vs -0.3 +/- 0.12 mmol/l P, P less than 0.05). Lactate threshold increased in both groups but the increase was greater in NP (P less than 0.05).
Details
- Title: Subtitle
- Effects of chronic beta-adrenergic blockade on exercise training in dogs
- Creators
- Eugene E Wolfel - University of Colorado HealthJoann Lindenfeld - Department of Medicine, University of Colorado Health Sciences Center, Denver 80262Jane Smoak - University of Colorado HealthLawrence D Horwitz - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.64(5), pp.1960-1967
- DOI
- 10.1152/jappl.1988.64.5.1960
- PMID
- 3391896
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 05/01/1988
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656595202771
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