Journal article
Effects of chronic hypertension on vasa vasorum in the thoracic aorta
Cardiovascular research, Vol.19(12), pp.777-781
1985
DOI: 10.1093/cvr/19.12.777
PMID: 4084935
Abstract
The outer layers of the thoracic aorta receive substantial blood flow through vasa vasorum within the aortic wall. Flow delivered via these channels is functionally important because medial necrosis occurs when vasa vasorum are ligated. If flow through vasa vasorum is limited in chronic hypertension, this could contribute to medial necrosis and, perhaps, aortic dissection. In these experiments, flow and conductance in vasa vasorum were assessed in twelve awake dogs with renal hypertension (arterial pressure = 127 +/- 4 mmHg [mean +/- SE]) and nine normotensive controls (arterial pressure = 100 +/- 3 mmHg [P less than 0.001]). At rest, blood flow delivered via vasa vasorum to the thoracic aorta was similar in hypertensive and normotensive dogs (5.2 +/- 0.9 and 4.8 +/- 0.4 ml . min-1 X 100 g-1 respectively). Thus, in hypertensive dogs, conductance of the vasa vasorum decreased to maintain flow constant. During maximal dilatation induced by iv adenosine (4.7 mumol . kg-1 per min) flow delivered via vasa vasorum increased by 100% in both hypertensive and normotensive dogs. Calculations of maximum conductance indicate that vasodilator capacity was decreased by 67% in vasa vasorum of hypertensive dogs. These data suggest that vasodilator capacity of vasa vasorum in the thoracic aorta is limited in chronic hypertension. This abnormality could contribute to the pathogenesis of medial necrosis and aortic dissection in hypertensive patients.
Details
- Title: Subtitle
- Effects of chronic hypertension on vasa vasorum in the thoracic aorta
- Creators
- M. L MARCUS - Univ. Iowa, cardiovascular centD. D HEISTAD - Univ. Iowa, cardiovascular centM. L ARMSTRONG - Univ. Iowa, cardiovascular centF. M ABBOUD - Univ. Iowa, cardiovascular cent
- Resource Type
- Journal article
- Publication Details
- Cardiovascular research, Vol.19(12), pp.777-781
- Publisher
- Oxford University Press; Oxford
- DOI
- 10.1093/cvr/19.12.777
- PMID
- 4084935
- ISSN
- 0008-6363
- eISSN
- 1755-3245
- Language
- English
- Date published
- 1985
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025680802771
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