Journal article
Effects of chronic lesions of the anteroventral region of the third ventricle on cardiac β-adrenoceptor function in conscious rats
Brain research, Vol.913(1), pp.82-85
2001
DOI: 10.1016/S0006-8993(01)02744-5
PMID: 11532250
Abstract
This study examined whether cardiac β-adrenoceptor (β-AR) function was altered in conscious rats with lesions surrounding the anteroventral third ventricle (AV3V). The findings were: (1) β
1,2-AR-mediated tachycardia was similar in sham and AV3V-lesion rats, (2) β
3- and/or atypical β-AR-mediated tachycardia elicited by isoproterenol (10 μg/kg, i.v.; ISO) was diminished in AV3V-lesion rats treated with β
1,2-AR antagonists, but was not in similarly-treated sham-lesion rats, and (3) the tachycardia elicited by the membrane permeable cAMP-analogue, 8-(4-chlorophenylthiol)-cAMP (10 μmol/kg, i.v.), was similar in AV3V- and sham-lesion rats. The possibility that increased plasma sodium/osmolality in AV3V-lesion rats down-regulated cardiac β
3- and/or atypical β-ARs, but not β
1,2-ARs or intracellular cAMP signaling is discussed.
Details
- Title: Subtitle
- Effects of chronic lesions of the anteroventral region of the third ventricle on cardiac β-adrenoceptor function in conscious rats
- Creators
- Erin J Whalen - Departments of Psychology, Pharmacology and Exercise Science, and The Cardiovascular Center, 11 Seashore Hall, University of Iowa, Iowa City, IA 52242-1407, USAG.H.M Schoorlemmer - Departments of Psychology, Pharmacology and Exercise Science, and The Cardiovascular Center, 11 Seashore Hall, University of Iowa, Iowa City, IA 52242-1407, USATerry G Beltz - Departments of Psychology, Pharmacology and Exercise Science, and The Cardiovascular Center, 11 Seashore Hall, University of Iowa, Iowa City, IA 52242-1407, USAAlan Kim Johnson - Departments of Psychology, Pharmacology and Exercise Science, and The Cardiovascular Center, 11 Seashore Hall, University of Iowa, Iowa City, IA 52242-1407, USAStephen J Lewis - Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.913(1), pp.82-85
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(01)02744-5
- PMID
- 11532250
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 2001
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984214760302771
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