Journal article
Effects of chronic oral quinidine on left ventricular performance
The American heart journal, Vol.101(6), pp.769-773
06/1981
DOI: 10.1016/0002-8703(81)90614-1
PMID: 7234655
Abstract
We studied the effects of 10 to 14 days of oral quinidine administration (200 mg every 8 hrs) on left ventricular (LV)
dP
dt
max and shortening fraction (%ΔD) in seve preinstrumented consclous dogs in the resting state, during atrial pacing at 120 bpm, and during an acute pressure load produced by intravenous phenylephrine. Dogs were studied before, during, and after oral quinidine administration with control measurements varying by < 10%. In the resting state, heart rate (85 ± 6 SEM vs 88 ± 7 bpm), LV end-diastolic pressure (7.2 ± 1.4 vs 6.7 ± 1.1 mm Hg), LV end-diastolic diameter (39.6 ± 3.2 vs 38.9 ± 2.7) did not differ (
p > 0.05) before or during quinidine, respectively. During atrial pacing LV
dP
dt
increased similarly during the control and quinidine periods (+ 13 and + 11%), and %ΔD decreased equally (−26% and −21%) during phenylephrine infusion off and on quinidine. Thus chronic oral quinidine administration in clinically therapeutic doses (serum quinidine levels 2.3 to 7.5 μg/ml) produced no depression in LV performance at rest or during an acute pressure load.
Details
- Title: Subtitle
- Effects of chronic oral quinidine on left ventricular performance
- Creators
- Robert A. O'Rourke - Cardiology Division, Department of Medicine, University of Texas Health Science Center San Antonio, Texas USALawrence D. Horwitz - The University of Texas Health Science Center at San Antonio
- Resource Type
- Journal article
- Publication Details
- The American heart journal, Vol.101(6), pp.769-773
- Publisher
- Mosby, Inc
- DOI
- 10.1016/0002-8703(81)90614-1
- PMID
- 7234655
- ISSN
- 0002-8703
- eISSN
- 1097-6744
- Language
- English
- Date published
- 06/1981
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656593802771
Metrics
4 Record Views