Journal article
Effects of congeneric polychlorinated biphenyls on liver and kidney retinoid levels
Chemosphere (Oxford), Vol.15(9), pp.1905-1908
1986
DOI: 10.1016/0045-6535(86)90480-7
Abstract
Liver and kidney retinol and retinyl palmitate levels were studied in male Sprague Dawley rats receiving a single ip injection of one of several polychlorinated biphenyls (PCBs) or DDT. Only the administration of 3,3′,4,4′-tetrachlorobiphenyl resulted in progressively lowered liver vitamin A levels (to 40 % of control values by day 7). During this time, kidney total vitamin A content increased 3 fold (due primarily to increased retinol content), but this increase was only equal to approximately
1
40
of total vitamin A which had disappeared from the liver. The activity of retinyl palmitate hydrolase, the key enzyme in the hydrolysis of hepatic retinyl palmitate, was not increased, indicating that this enzyme is probably not involved in the depletion of liver vitamin A stores by 3,3′-4,4′-tetrachlorobiphenyl.
Details
- Title: Subtitle
- Effects of congeneric polychlorinated biphenyls on liver and kidney retinoid levels
- Creators
- V. Azais - Laboratoire des Sciences de la Consommation, INRA-CNRZ, 78350 Jouy-en-Josas, FranceG. Pascal - Laboratoire des Sciences de la Consommation, INRA-CNRZ, 78350 Jouy-en-Josas, FranceM. Arand - Johannes Gutenberg University MainzF. Oesch - Johannes Gutenberg University MainzL.W. Robertson - Johannes Gutenberg University Mainz
- Resource Type
- Journal article
- Publication Details
- Chemosphere (Oxford), Vol.15(9), pp.1905-1908
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/0045-6535(86)90480-7
- ISSN
- 0045-6535
- eISSN
- 1879-1298
- Grant note
- DOI: 10.13039/501100001659, name: Deutsche Forschungsgemeinschaft, award: SF~ 302
- Language
- English
- Date published
- 1986
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984363576502771
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