Effects of depression on working memory in presymptomatic Huntington's disease

Carissa NEHL; Rebecca E READY; Joanne HAMILTON; Jane S PAULSEN

doi:10.1176/jnp.13.3.342

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Effects of depression on working memory in presymptomatic Huntington's disease

Journal article

Peer reviewed

Effects of depression on working memory in presymptomatic Huntington's disease

Carissa NEHL, Rebecca E READY, Joanne HAMILTON and Jane S PAULSEN

The journal of neuropsychiatry and clinical neurosciences, Vol.13(3), pp.342-346

2001

DOI: 10.1176/jnp.13.3.342

PMID: 11514640

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Abstract

Cognitive decline may precede motor symptoms in Huntington's disease (HD). Depression is common in HD and has also been linked with cognitive impairment. The contribution of depression to cognition in individuals presymptomatic for HD (N=15) was investigated. Tests from the Cambridge Automated Neuropsychological Assessment Battery measured visual and working memory. Depression was assessed with the Beck Depression Inventory and the Unified Huntington's Disease Rating Scale. Depressed mood and estimated time to disease onset, calculated by using DNA mutation length, both were significant predictors of working memory performance. Findings are consistent with and contribute to existing research with individuals presymptomatic for HD, identifying a potentially remediable contribution to cognitive decline (i.e., depressed mood).

Neurology

Biological and medical sciences

Medical sciences

Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases

Details

Title: Subtitle: Effects of depression on working memory in presymptomatic Huntington's disease
Creators: Carissa NEHL - Department of Psychiatry, University of California-San Diego School of Medicine, San Diego, California, United States
Rebecca E READY - Department of Psychiatry, University of California-San Diego School of Medicine, San Diego, California, United States
Joanne HAMILTON - Department of Psychiatry, University of California-San Diego School of Medicine, San Diego, California, United States
Jane S PAULSEN - Department of Psychiatry, University of California-San Diego School of Medicine, San Diego, California, United States
Resource Type: Journal article
Publication Details: The journal of neuropsychiatry and clinical neurosciences, Vol.13(3), pp.342-346
Publisher: American Psychiatric Press
DOI: 10.1176/jnp.13.3.342
PMID: 11514640
ISSN: 0895-0172
eISSN: 1545-7222
Language: English
Date published: 2001
Academic Unit: Psychiatry; Psychological and Brain Sciences
Record Identifier: 9984083243702771

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