Journal article
Effects of diet and sexual maturation on low-density lipoprotein cholesterol during puberty: the Dietary Intervention Study in Children (DISC)
Circulation (New York, N.Y.), Vol.96(8), pp.2526-2533
10/21/1997
DOI: 10.1161/01.CIR.96.8.2526
PMID: 9355889
Abstract
The Dietary Intervention Study in Children (DISC) is a multicenter, randomized, controlled clinical trial designed to examine the efficacy and safety of a dietary intervention to reduce serum LDL cholesterol (LDL-C) in children with elevated LDL-C.
The effects of dietary intake of fat and cholesterol and of sexual maturation and body mass index (BMI) on LDL-C were examined in a 3-year longitudinal study of 663 boys and girls (age 8 to 10 years at baseline) with elevated LDL-C levels. Multiple linear regression was used to predict LDL-C at 3 years. For boys, LDL-C decreased by 0.018 mmol/L for each 10 mg/4.2 MJ decrease in dietary cholesterol (P<.05). For girls, no single nutrient was significant in the model, but a treatment group effect was evident (P<.05). In both sexes, BMI at 3 years and LDL-C at baseline were significant and positive predictors of LDL-C levels. In boys, the average LDL-C level was 0.603 mmol/L lower at Tanner stage 4+ than at Tanner stage 1 (P<.01). In girls, the average LDL-C level was 0.274 mmol/L lower at Tanner stage 4+ than at Tanner stage 1 (P<.05).
In pubertal children, sexual maturation, BMI, dietary intervention (in girls), and dietary cholesterol (in boys) were significant in determining LDL-C. Sexual maturation was the factor associated with the greatest difference in LDL-C. Clinicians screening for dyslipidemia or following dyslipidemic children should be aware of the powerful effects of pubertal change on measurements of lipoproteins.
Details
- Title: Subtitle
- Effects of diet and sexual maturation on low-density lipoprotein cholesterol during puberty: the Dietary Intervention Study in Children (DISC)
- Creators
- Peter O Kwiterovich Jr - The Johns Hopkins University, Baltimore, Md, USABruce A BartonRobert P McMahonEva ObarzanekSally HunsbergerDenise Simons-MortonSue Y S KimmLisa Aronson FriedmanNorman LasserAlan RobsonRonald LauerVictor StevensLinda Van HornSamuel GiddingL SnetselaarVirginia W HartmullerMerwyn Greenlick - Kaiser Permanente Center for Health ResearchFrank Franklin Jr
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.96(8), pp.2526-2533
- DOI
- 10.1161/01.CIR.96.8.2526
- PMID
- 9355889
- NLM abbreviation
- Circulation
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Publisher
- United States
- Grant note
- U01-HL-37947 / NHLBI NIH HHS U01-HL-37954 / NHLBI NIH HHS U01-HL-37948 / NHLBI NIH HHS
- Language
- English
- Date published
- 10/21/1997
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9983995027202771
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