Journal article
Effects of dimethyl sulfoxide on systemic and cerebral hemodynamic variables in the ischemic canine myocardium
Critical care medicine, Vol.15(7), pp.656-660
07/1987
DOI: 10.1097/00003246-198707000-00006
PMID: 3595155
Abstract
The effects of dimethyl sulfoxide (DMSO) infusion on cerebral blood flow (CBF) and systemic hemodynamics were studied in a canine model of myocardial ischemia. Immediately after ligation, cardiac output dropped from 2.09 ± 0.11 (SEM) in the control group and 1.79 ± 0.13 in the DMSO group to 1.07 ± 0.21 and 1.0 ± 0.08 L/min, respectively; there were no significant differences for 2 h. By the third hour and thereafter, the DMSO group had a significantly (p < .05) higher cardiac output (1.65 ± 0.08 L/min) than the control group (1.15 ± 0.10 L/min). The cardiac output increase at 3 h was accompanied by significantly (p <.05) lower systemic vascular resistance (SVR) in the DMSO group (5315 ± 248 dyne · sec/cm) as compared to the control group (7892 ± 442 dyne · sec/cm). There were no significant differences in heart rate, mean arterial pressure, pulmonary artery wedge pressure, or cerebral or pulmonary resistances in the control as compared to the DMSO group. Higher CBF values were noted at one hour and thereafter in the DMSO as compared to the control group (p < .05). Low-dose DMSO given as an iv bolus improved cardiac output and CBF and lowered SVR in this canine model of experimental myocardial ischemia.
Details
- Title: Subtitle
- Effects of dimethyl sulfoxide on systemic and cerebral hemodynamic variables in the ischemic canine myocardium
- Creators
- James M Levett - From the Department of Surgery, Sections of Cardiac and Neurosurgery. University of Chicago Hospitals and Clinics, Chicago, ILLydia M JohnsNora M GrinaBrian F MullanJohn F KramerJohn F Mullan
- Resource Type
- Journal article
- Publication Details
- Critical care medicine, Vol.15(7), pp.656-660
- Publisher
- Williams & Wilkins
- DOI
- 10.1097/00003246-198707000-00006
- PMID
- 3595155
- ISSN
- 0090-3493
- eISSN
- 1530-0293
- Language
- English
- Date published
- 07/1987
- Academic Unit
- Radiology; Internal Medicine
- Record Identifier
- 9984094876102771
Metrics
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