Journal article
Effects of donor cause of death, ischemia time, inotrope exposure, troponin values, cardiopulmonary resuscitation, electrocardiographic and echocardiographic data on recipient outcomes: A review of the literature
Pediatric transplantation, Vol.24(3), pp.e13676-n/a
05/2020
DOI: 10.1111/petr.13676
PMID: 32198808
Abstract
Heart transplantation has become standard of care for pediatric patients with either end-stage heart failure or inoperable congenital heart defects. Despite increasing surgical complexity and overall volume, however, annual transplant rates remain largely unchanged. Data demonstrating pediatric donor heart refusal rates of 50% suggest optimizing donor utilization is critical. This review evaluated the impact of donor characteristics surrounding the time of death on pediatric heart transplant recipient outcomes.
An extensive literature review was performed to identify articles focused on donor characteristics surrounding the time of death and their impact on pediatric heart transplant recipient outcomes.
Potential pediatric heart transplant recipient institutions commonly receive data from seven different donor death-related categories with which to determine organ acceptance: cause of death, need for CPR, serum troponin, inotrope exposure, projected donor ischemia time, electrocardiographic, and echocardiographic results. Although DITs up to 8 hours have been reported with comparable recipient outcomes, most data support minimizing this period to <4 hours. CVA as a cause of death may be associated with decreased recipient survival but is rare in the pediatric population. Otherwise, however, in the setting of an acceptable donor heart with a normal echocardiogram, none of the other data categories surrounding donor death negatively impact pediatric heart transplant recipient survival.
Echocardiographic evaluation is the most important donor clinical information following declaration of brain death provided to potential recipient institutions. Considering its relative importance, every effort should be made to allow direct image visualization.
Details
- Title: Subtitle
- Effects of donor cause of death, ischemia time, inotrope exposure, troponin values, cardiopulmonary resuscitation, electrocardiographic and echocardiographic data on recipient outcomes: A review of the literature
- Creators
- Michael A McCulloch - University of Virginia Children's HospitalWarren A Zuckerman - Morgan Stanley Children's HospitalThomas Möller - Oslo University HospitalKenneth Knecht - Arkansas Children's HospitalKimberly Y Lin - Children's Hospital of PhiladelphiaGary S Beasley - Le Bonheur Children's HospitalDavid M Peng - University of MichiganDimpna C Albert - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi ArabiaOliver Miera - Deutsches Herzzentrum der CharitéAnne I Dipchand - University of TorontoRichard Kirk - The University of Texas Southwestern Medical CenterRyan R Davies - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- Pediatric transplantation, Vol.24(3), pp.e13676-n/a
- DOI
- 10.1111/petr.13676
- PMID
- 32198808
- NLM abbreviation
- Pediatr Transplant
- ISSN
- 1397-3142
- eISSN
- 1399-3046
- Language
- English
- Date published
- 05/2020
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984353940302771
Metrics
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