Journal article
Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo
British journal of anaesthesia : BJA, Vol.81(6), pp.905-912
12/01/1998
DOI: 10.1093/bja/81.6.905
PMID: 10211018
Abstract
It is known that volatile anaesthetics protect myocardial tissue against ischaemic and reperfusion injury in vitro. In this investigation, we have determined the effects of the inhalation anaesthetics, enflurane, isoflurane, sevoflurane and desflurane, administered only during early reperfusion, on myocardial reperfusion injury in vivo. Fifty chloralose-anaesthetized rabbits were subjected to 30 min of occlusion of a major coronary artery followed by 120 min of reperfusion. Left ventricular pressure (LVP, tip-manometer), cardiac output (CO, ultrasonic flow probe) and infarct size (triphenyltetrazolium staining) were determined. During the first 15 min of reperfusion, five groups of 10 rabbits each received 1 MAC of enflurane (enflurane group), isoflurane (isoflurane group), sevoflurane (sevoflurane group) or desflurane (desflurane group), and 10 rabbits served as untreated controls (control group). Haemodynamic baseline values were similar between groups (mean LVP 106 (SEM 2) mmHg; CO 281 (7) ml min-1). During coronary occlusion, LVP and CO were reduced to the same extent in all groups (LVP 89% of baseline; CO 89%). Administration of inhalation anaesthetics during early reperfusion further reduced both variables, but they recovered after discontinuation of the anaesthetics to values not different from control animals. Infarct size was reduced from 49 (5)% of the area at risk in the control group to 32 (3)% in the desflurane group (P = 0.021), and to 36 (2)% in the sevoflurane group (P = 0.097). In the enflurane group, infarct size was 39 (5)% (P = 0.272). Isoflurane had no effect on infarct size (48 (5)%, P = 1.000). The results show that desflurane and sevoflurane markedly reduced infarct size and therefore can protect myocardium against reperfusion injury in vivo. Enflurane had only a marginal effect and isoflurane offered no protection against reperfusion injury in vivo. These different effects suggest different protective mechanisms at the cellular level.
Details
- Title: Subtitle
- Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo
- Creators
- B Preckel - Heinrich Heine University DüsseldorfW Schlack - Institut für Klinische Anaesthesiologie, Heinrich-Heine-Universität Düsseldorf, Postfach 10 10 07, 40001 Düsseldorf, GermanyT Comfere - Physiologisches Institut I, Heinrich-Heine-Universität Düsseldorf, Postfach 10 10 07, 40001 Düsseldorf, GermanyD Obal - Physiologisches Institut I, Heinrich-Heine-Universität Düsseldorf, Postfach 10 10 07, 40001 Düsseldorf, GermanyH Barthel - Physiologisches Institut I, Heinrich-Heine-Universität Düsseldorf, Postfach 10 10 07, 40001 Düsseldorf, GermanyV Thämer - Physiologisches Institut I, Heinrich-Heine-Universität Düsseldorf, Postfach 10 10 07, 40001 Düsseldorf, Germany
- Resource Type
- Journal article
- Publication Details
- British journal of anaesthesia : BJA, Vol.81(6), pp.905-912
- Publisher
- Oxford University Press
- DOI
- 10.1093/bja/81.6.905
- PMID
- 10211018
- ISSN
- 0007-0912
- eISSN
- 1471-6771
- Language
- English
- Date published
- 12/01/1998
- Academic Unit
- Anesthesia
- Record Identifier
- 9984696578902771
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