Journal article
Effects of enhanced ventricular filling on cardiac pump performance in exercising dogs
Journal of applied physiology (1985), Vol.59(6), pp.1886-1890
12/1985
DOI: 10.1152/jappl.1985.59.6.1886
PMID: 2416732
Abstract
The extent to which the normal increase in stroke volume during exercise can be augmented by increasing preload by dextran infusion was studied in seven dogs. Each dog ran 3 min on a level treadmill at mild (3-4 mph), moderate (6-8 mph), and severe (9-13 mph) loads during the control study and immediately after 10% dextran 14 ml/kg iv. During severe exercise dextran-augmented stroke volume (+5.4 ml or 19% vs. exercise without dextran, P<0.01) and left ventricular end-diastolic diameter and pressure did not change heart rate, aortic pressure, or maximum derivative of left ventricular pressure but decreased systemic vascular resistance by 16%. Similar increases in stroke volume and preload dextran occurred during mild and moderate exercise when arterial pressure and heart rate were unchanged or increased and systemic vascular resistance was decreased. Thus altering preload above those levels normally encountered during exercise is a potential mechanism to increase stroke volume and cardiac output.
Details
- Title: Subtitle
- Effects of enhanced ventricular filling on cardiac pump performance in exercising dogs
- Creators
- Lawrence D Horwitz - University of Colorado HealthJoann Lindenfeld - Univ. Colorado health sci. center
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.59(6), pp.1886-1890
- Publisher
- American Physiological Society
- DOI
- 10.1152/jappl.1985.59.6.1886
- PMID
- 2416732
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 12/1985
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656538602771
Metrics
10 Record Views