Journal article
Effects of ethinyl estradiol-cyproterone acetate treatment on metabolic syndrome, fat distribution and carotid intima media thickness in polycystic ovary syndrome
Gynecological endocrinology, Vol.28(4), pp.245-248
04/01/2012
DOI: 10.3109/09513590.2011.613971
PMID: 21961995
Abstract
Objective: To evaluate the effects of ethinyl estradiol-cyproterone acetate (EE-CA) treatment on metabolic and cardiovascular risk factors, and body fat distribution in polycystic ovary syndrome (PCOS) after 6-month treatment. Subjects and methods: Thirty women with PCOS were evaluated before and after 6 months of EE-CA treatment. Anthropometrical measurements, hormonal levels, lipid and glucose profile were evaluated. Body fat thickness in four regions and carotid intima media thickness (IMT) were measured. Interval change in antropometric measurements, glucose and lipid profile, carotid IMT and body fat distribution was evaluated before and after 6-month EE-CA treatment. Results: Ferriman-Gallwey score and serum testosterone levels were significantly decreased after EE-CA treatment (p < 0.01). No significant effect was detected on insulin resistance, lipid profile and carotid artery IMT. The visceral, subcutaneous and preperitoneal fat thicknesses decreased, and mid-thigh fat thickness increased after treatment period. However, only the alteration in subcutaneous fat thickness achieved a statistical significance (p < 0.01). Conclusion: The EE-CA is an effective regimen in treatment of hirsutism and menstrual regulation. Although it provides significant decrease in subcutaneous fat thickness after 6-month treatment, it has no beneficial effect with respect to visceral fat thickness, metabolic and cardiovascular risk factors.
Details
- Title: Subtitle
- Effects of ethinyl estradiol-cyproterone acetate treatment on metabolic syndrome, fat distribution and carotid intima media thickness in polycystic ovary syndrome
- Creators
- Aysun Karabulut - Denizli Devlet HastanesiSemra Demirlenk - Denizli Devlet HastanesiOsman Şevket - Denizli Devlet Hastanesi
- Resource Type
- Journal article
- Publication Details
- Gynecological endocrinology, Vol.28(4), pp.245-248
- DOI
- 10.3109/09513590.2011.613971
- PMID
- 21961995
- NLM abbreviation
- Gynecol Endocrinol
- ISSN
- 0951-3590
- eISSN
- 1473-0766
- Publisher
- Taylor & Francis
- Number of pages
- 4
- Language
- English
- Date published
- 04/01/2012
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9985123698702771
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