Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials

Chao Gao; Yang Liu; Yong Gan; Wei Bao; Xiaolin Peng; Qingbin Xing; Huiyu Gao; Jianqiang Lai; Liegang Liu; Zhu Wang; Yuexin Yang

doi:10.1186/s12944-020-01214-w

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Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials

Journal article

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Peer reviewed

Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials

Chao Gao, Yang Liu, Yong Gan, Wei Bao, Xiaolin Peng, Qingbin Xing, Huiyu Gao, Jianqiang Lai, Liegang Liu, Zhu Wang, …

Lipids in health and disease, Vol.19(1), pp.87-87

05/08/2020

DOI: 10.1186/s12944-020-01214-w

PMCID: PMC7206824

PMID: 32384902

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Abstract

Previous studies have yielded inconsistent findings on the role of fish oil in type 2 diabetes mellitus (T2DM). We systematically summarized the available evidence from randomized controlled trials (RCT) and aimed to investigate the effects of fish oil supplementation on glucose control and lipid levels among patients with T2DM. A comprehensive literature search was performed in electronic databases (PubMed, ProQuest, Cochrane Library, CNKI, VIP, and Wanfang) to identify all relevant RCTs which were published up to May 31st, 2019. We used Modified Jadad Score system to evaluate the quality of each included RCT. The pooled effects were estimated using random-effects model and presented as standardized mean differences with 95% confidence intervals. A total of 12 RCTs were included in this meta-analysis. There was no significant difference in glucose control outcomes comparing fish oil supplementation to placebo. The effect size of fasting plasma glucose (FPG) was 0.13 (95% CI: - 0.03 to 0.28, p > 0.05). No marked change was observed in fasting insulin (FINS), glycosylated hemoglobin (HbA1c), and HOMA of insulin resistance (HOMA-IR) levels. Fish oil supplementation was associated with a decrease of triglyceride (TG) level by - 0.40 (95%CI: - 0.53 to - 0.28, p < 0.05), and an increase of high density lipoprotein (HDL) cholesterol level by 0.21 (95%CI: 0.05 to 0.37, p < 0.05). In subgroup analysis, HDL cholesterol level was higher among Asian and low-dose(< 2 g/d n-3 PUFA) subgroups compared to their counterparts (p < 0.05). TG level was lower in mid and long duration groups, along with an inconspicuous difference in short duration group. This meta-analysis shows that among patients with T2DM, fish oil supplementation leads to a favorable blood lipids profile but does not improve glucose control.

Adult

Aged

Blood Glucose - metabolism

Cholesterol, HDL - blood

Cholesterol, LDL - blood

Diabetes Mellitus, Type 2 - blood

Diabetes Mellitus, Type 2 - diet therapy

Diabetes Mellitus, Type 2 - pathology

Dietary Supplements

Fasting - physiology

Female

Fish Oils - administration & dosage

Glycated Hemoglobin A - metabolism

Humans

Insulin - blood

Insulin Resistance

Male

Middle Aged

Randomized Controlled Trials as Topic

Triglycerides - blood

Details

Title: Subtitle: Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials
Creators: Chao Gao - Chinese Center For Disease Control and Prevention
Yang Liu - Chinese Center For Disease Control and Prevention
Yong Gan - Huazhong University of Science and Technology
Wei Bao - University of Iowa
Xiaolin Peng - Shenzhen Nanshan Center for Chronic Disease Control
Qingbin Xing - Chinese Center For Disease Control and Prevention
Huiyu Gao - Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China
Jianqiang Lai - Chinese Center For Disease Control and Prevention
Liegang Liu - Huazhong University of Science and Technology
Zhu Wang - Chinese Center For Disease Control and Prevention
Yuexin Yang - Chinese Center For Disease Control and Prevention
Resource Type: Journal article
Publication Details: Lipids in health and disease, Vol.19(1), pp.87-87
DOI: 10.1186/s12944-020-01214-w
PMID: 32384902
PMCID: PMC7206824
NLM abbreviation: Lipids Health Dis
ISSN: 1476-511X
eISSN: 1476-511X
Grant note: No.81602858 / National Natural Science Foundation of China No.YESS20160164, 2016QNRC001 / Young Elite Scientists Sponsorship Program by CAST CNS2015067B / 2015 Chinese Nutrition Society (CNS) Nutrition Research Foundation-DSM Research Fund
Language: English
Date published: 05/08/2020
Academic Unit: Epidemiology
Record Identifier: 9984364376502771

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