Journal article
Effects of fluoride intake on cortical and trabecular bone microstructure at early adulthood using multi-row detector computed tomography (MDCT)
Bone (New York, N.Y.), Vol.146, pp.115882-115882
05/2021
DOI: 10.1016/j.bone.2021.115882
PMID: 33578032
Abstract
The aim of this study was to examine the effects of period-specific and cumulative fluoride (F) intake on bone at the levels of cortical and trabecular bone microstructural outcomes at early adulthood using emerging multi-row detector computed tomography (MDCT)-based novel techniques.
Ultra-high resolution MDCT distal tibia scans were collected at age 19 visits under the Iowa Bone Development Study (IBDS), and cortical and trabecular bone microstructural outcomes were computed at the distal tibia using previously validated methods. CT scans of a tissue characterization phantom were used to calibrate CT numbers (Hounsfield units) into bone mineral density (mg/cc). Period-specific and cumulative F intakes from birth up to the age of 19 years were assessed for IBDS participants through questionnaire, and their relationships with MDCT-derived bone microstructural outcomes were examined using bivariable and multivariable analyses, adjusting for height, weight, maturity offset (years since age of peak height velocity (PHV)), physical activity (questionnaire for adolescents (PAQ-A)), healthy eating index version 2010 (HEI-2010) scores, and calcium and protein intakes.
MDCT distal tibia scans were acquired for 324 participants from among the total of 329 participants at age 19 visits. No motion artifacts were observed in any MDCT scans, and all images were successfully processed to measure cortical and trabecular bone microstructural outcomes. At early adulthood, males were observed to have stronger trabecular bone microstructural features, as well as thicker cortical bone (p < 0.01), as compared to age-similar females; however, females were found to have less cortical bone porosity as compared to males. Among participants with available F intake estimates (75 to 91% of the 324 with MDCT scans, depending on the period-specific F intake measure), no statistically significant associations were detected between any period-specific or cumulative F intake and bone microstructural outcomes of the tibia at the p < 0.01 level. Only for females, statistically suggestive associations (p < 0.05) were found between recent F intake (from 14 to 19 years) and trabecular mean plate width and trabecular thickness at the tibia. Those associations became somewhat weaker, but still statistically suggestive, for trabecular thickness in fully adjusted analysis with height, weight, PHV, calcium and protein intake, and HEI-2010 and PAQ-A scores as covariates.
The findings show that the effects of lifelong or period-specific F intake from combined sources for adolescents typical to the United States Midwest region are not strongly associated with bone microstructural outcomes at age 19 years. These findings are generally consistent with previously reported results of IBDS analyses, which further confirms that effects of lifelong or period-specific F intake on skeletons in early adulthood are absent or weak, even at the levels of cortical and trabecular bone microstructural details.
•No evidence of a significant effect of lifetime fluoride intake on bone microstructure at early adulthood•Iowa Bone Development Study cohort at age 19 years•High resolution multi-row detector CT imaging at the distal tibia•Quantitative measures of cortical and trabecular bone microstructure•Individual trabecular plate-rod and longitudinal-transverse characterization of the distal tibia
Details
- Title: Subtitle
- Effects of fluoride intake on cortical and trabecular bone microstructure at early adulthood using multi-row detector computed tomography (MDCT)
- Creators
- Punam K Saha - University of IowaReem Reda Oweis - Department of Preventive and Community Dentistry, College of Dentistry, Iowa City, IA, USA.Xiaoliu Zhang - University of IowaElena Letuchy - Department of Epidemiology, College of Public Health, Iowa City, IA, USA.Julie M Eichenberger-Gilmore - Department of Epidemiology, College of Public Health, Iowa City, IA, USATrudy L Burns - Department of Epidemiology, College of Public Health, Iowa City, IA, USA.John J Warren - Department of Preventive and Community Dentistry, College of Dentistry, Iowa City, IA, USA.Kathleen F Janz - Department of Health and Human Physiology, College of Liberal Arts and Sciences, Iowa City, IA, USA.James C Torner - Department of Epidemiology, College of Public Health, Iowa City, IA, USA.Linda G Snetselaar - Department of Epidemiology, College of Public Health, Iowa City, IA, USA.Steven M Levy - Department of Preventive and Community Dentistry, College of Dentistry, Iowa City, IA, USA; Department of Epidemiology, College of Public Health, Iowa City, IA, USA.
- Resource Type
- Journal article
- Publication Details
- Bone (New York, N.Y.), Vol.146, pp.115882-115882
- DOI
- 10.1016/j.bone.2021.115882
- PMID
- 33578032
- NLM abbreviation
- Bone
- ISSN
- 8756-3282
- eISSN
- 1873-2763
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: NIH; DOI: 10.13039/100008893, name: The University of Iowa
- Language
- English
- Date published
- 05/2021
- Academic Unit
- Preventive and Community Dentistry; Neurology; Radiology; Electrical and Computer Engineering; Epidemiology; Surgery; Pediatric Dentistry; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Neurosurgery; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984197094502771
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