Journal article
Effects of frequent marijuana use on memory-related regional cerebral blood flow
Pharmacology, biochemistry and behavior, Vol.72(1-2), pp.237-250
05/2002
DOI: 10.1016/s0091-3057(01)00771-7
PMID: 11900794
Abstract
It is uncertain whether frequent marijuana use adversely affects human brain function. Using positron emission tomography (PET), memory-related regional cerebral blood flow was compared in frequent marijuana users and nonusing control subjects after 26+ h of monitored abstention. Memory-related blood flow in marijuana users, relative to control subjects, showed decreases in prefrontal cortex, increases in memory-relevant regions of cerebellum, and altered lateralization in hippocampus. Marijuana users differed most in brain activity related to episodic memory encoding. In learning a word list to criterion over multiple trials, marijuana users, relative to control subjects, required means of 2.7 more presentations during initial learning and 3.1 more presentations during subsequent relearning. In single-trial recall, marijuana users appeared to rely more on short-term memory, recalling 23% more than control subjects from the end of a list, but 19% less from the middle. These findings indicate altered memory-related brain function in marijuana users.
Details
- Title: Subtitle
- Effects of frequent marijuana use on memory-related regional cerebral blood flow
- Creators
- Robert I Block - Department of Anesthesia, University of Iowa, Room 5140, Westlawn Building, Iowa City, IA 52242, USA. robert-block@uiowa.eduDaniel S O'LearyRichard D HichwaJean C AugustinackLaura L Boles PontoM M GhoneimStephan ArndtRichard R HurtigG Leonard WatkinsJames A HallPeter E NathanNancy C Andreasen
- Resource Type
- Journal article
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.72(1-2), pp.237-250
- DOI
- 10.1016/s0091-3057(01)00771-7
- PMID
- 11900794
- NLM abbreviation
- Pharmacol Biochem Behav
- ISSN
- 0091-3057
- eISSN
- 1873-5177
- Publisher
- United States
- Grant note
- DA10554 / NIDA NIH HHS RR00059 / NCRR NIH HHS
- Language
- English
- Date published
- 05/2002
- Academic Unit
- Radiology; Communication Sciences and Disorders; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Physics and Astronomy; Radiation Oncology; Nursing; Anesthesia; Injury Prevention Research Center
- Record Identifier
- 9984003931902771
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