Journal article
Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes
Life sciences (1973), Vol.76(10), pp.1111-1121
2005
DOI: 10.1016/j.lfs.2004.08.014
PMID: 15620575
Abstract
Ginkgo biloba extract (GBE), a valuable natural product for cerebral and cardiovascular diseases, is mainly composed of two classes of constituents: terpene lactones (e.g., ginkgolide A and B, bilobalide) and flavone glycosides (e.g., quercetin and kaempferol). Its electrophysiological action in heart is yet unclear. In the present study, using whole-cell patch clamp technique, we investigated electrophysiological effects of GBE on cation channel currents in ventricular myocytes isolated from rat hearts. We found that GBE 0.01–0.1% inhibited significantly the sodium current (I
Na), L-type calcium current (I
Ca) and transient outward potassium current (IK
to) in a concentration-dependent manner. Surprisingly, its main ingredients, ginkgolide A (GB A), ginkgolide B (GB B) and bilobalide (GB BA) at 0.1 mM did not exhibit any significant effect on these cation channel currents. These results suggested that GBE is a potent non-selective cation channel modulator in cardiaomyocytes. Other constituents (rather than GB A, GB B and GB BA) might be responsible for the observed inhibitory effects of GBE on cation channels.
Details
- Title: Subtitle
- Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes
- Creators
- Biyi Chen - Section of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, ChinaJingxia Cai - Section of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, ChinaLong-Sheng Song - Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD, USAXiaoqing Wang - Department of Physiology, Kunming Medical College, Kunming, ChinaZhihe Chen - Yunnan Province Key Laboratory of Pharmacology for Natural Products, Kunming Medical College, Kunming, China
- Resource Type
- Journal article
- Publication Details
- Life sciences (1973), Vol.76(10), pp.1111-1121
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.lfs.2004.08.014
- PMID
- 15620575
- ISSN
- 0024-3205
- eISSN
- 1879-0631
- Language
- English
- Date published
- 2005
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9984094729902771
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