Journal article
Effects of implanting a long-term left ventricle assist device on post-transplant outcomes
International journal of artificial organs, Vol.44(1), pp.39-45
01/2021
DOI: 10.1177/0391398820914626
PMID: 32329386
Abstract
An increasing number of patients are receiving left ventricle assist devices as a bridge to heart transplantation. The aim of this study was to determine the difference between patients who received transplants from a left ventricle assist device and those who underwent heart transplantation without a prior left ventricle assist device implantation.
The study included patients who underwent heart transplantation in our institute between January 2010 and November 2018. The following clinical variables were evaluated: donor characteristics, patient's pre-transplant demographical data, post-transplant data, and patient survival. Cardiac allograft vasculopathy progression was prospectively examined (after 1 month and 12 months after heart transplantation) by coronary optical coherence tomography. We were interested in the difference in 1- and 5-year survival between the left ventricle assist device and non-left ventricle assist device groups.
A total of 248 patients were identified; out of them, 48 patients received a left ventricle assist device before heart transplantation, whereas 200 had transplants with no prior left ventricle assist device implantation. There were no significant differences in any donor characteristics. The mean duration of cardiopulmonary bypass time in the non-left ventricle assist device group was 156 versus 175 min in the left ventricle assist device group (
= 0.009), blood loss was 650 versus 1045 mL (
< 0.001), the need to implant an extracorporeal membrane oxygenation was 10% versus 23% (
= 0.02). There was no difference in cardiac allograft vasculopathy progression between the groups 1 year after heart transplantation (
= 0.528). The 1- and 5-year survival, according to Kaplan-Meier, was 80% and 70% in the left ventricle assist device group, compared to 80% and 73%, respectively, in the non-left ventricle assist device group (Log-rank test:
= 0.945).
Our results indicate that patients undergoing heart transplantation from left ventricle assist devices suffer significantly more from intraoperative and post-operative complications; however, only insignificant cardiac allograft vasculopathy progression and survival differences between the two groups were observed.
Details
- Title: Subtitle
- Effects of implanting a long-term left ventricle assist device on post-transplant outcomes
- Creators
- Helena Bedanova - Center of Cardiovascular and Transplant Surgery Brno, Brno, Czech Republic.Michal Pazdernik - Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.Milan Sonka - University of IowaChen Zhi - University of IowaJan Krejci - Masaryk UniversityMarie Novakova - Masaryk UniversityPetr Dobsak - Masaryk UniversityPetr Nemec - Center of Cardiovascular and Transplant Surgery Brno, Brno, Czech Republic.
- Resource Type
- Journal article
- Publication Details
- International journal of artificial organs, Vol.44(1), pp.39-45
- DOI
- 10.1177/0391398820914626
- PMID
- 32329386
- NLM abbreviation
- Int J Artif Organs
- ISSN
- 0391-3988
- eISSN
- 1724-6040
- Publisher
- Sage Journals
- Grant note
- DOI: 10.13039/501100003243, name: ministerstvo zdravotnictvî ceské republiky, award: 16-27465A
- Language
- English
- Date published
- 01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984187364002771
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