Effects of indapamide, a thiazide-like diuretic, on structure of cerebral arterioles in hypertensive rats

Jean-Marc Chillon; Gary L Baumbach

doi:10.1161/01.HYP.0000122874.21730.81

Back

Effects of indapamide, a thiazide-like diuretic, on structure of cerebral arterioles in hypertensive rats

Journal article

Open access

Peer reviewed

Effects of indapamide, a thiazide-like diuretic, on structure of cerebral arterioles in hypertensive rats

Jean-Marc Chillon and Gary L Baumbach

Hypertension (Dallas, Tex. 1979), Vol.43(5), pp.1092-1097

05/2004

DOI: 10.1161/01.HYP.0000122874.21730.81

PMID: 15007039

Files and links (1)

url

https://doi.org/10.1161/01.HYP.0000122874.21730.81View

Published (Version of record) Open Access

Abstract

We examined the effects of indapamide, a thiazide-like diuretic, on cerebral arterioles in spontaneously hypertensive rats (SHR). The structure and mechanics of cerebral arterioles were examined in untreated Wistar Kyoto rats (WKY) and SHR that were untreated or treated for 3 months with a low (1 mg/kg per day) or a high (10 mg/kg per day) dose of indapamide. We measured pressure, diameter, and cross-sectional area of the vessel wall (CSA) in maximally-dilated (EDTA) cerebral arterioles. Treatment of SHR with the high dose of indapamide normalized cerebral arteriolar mean pressure (62+/-4 [mean+/-SEM] versus 59+/-3 mm Hg in WKY and 88+/-6 mm Hg in untreated SHR; P<0.05), pulse pressure (13+/-1 versus 10+/-1 mm Hg in WKY and 20+/-1 mm Hg in untreated SHR; P<0.05), and CSA (1080+/-91 versus 1100+/-48 microm2 in WKY and 1439+/-40 microm2 in untreated SHR; P<0.05). In contrast, treatment of SHR with the low dose of indapamide did not normalize arteriolar mean (72+/-3) and pulse pressure (20+/-1 mm Hg), but did normalize CSA (1091+/-52 microm2). Treatment with either dose of indapamide failed to increase external diameter in cerebral arterioles of SHR (89+/-4 and 92+/-4 microm, respectively, versus 103+/-6 microm in WKY and 87+/-4 microm in untreated SHR). Finally, treatment with indapamide attenuated the rightward shift of the stress-strain curve in SHR, suggesting that treatment with indapamide attenuated increases in distensibility of cerebral arterioles in SHR. These findings suggest that, whereas thiazide-like diuretics may not attenuate eutrophic inward remodeling of cerebral arterioles in SHR, they may attenuate hypertrophic inward remodeling via a mechanism unrelated to their pressor effects.

Animals

Antihypertensive Agents - administration & dosage

Antihypertensive Agents - pharmacology

Antihypertensive Agents - therapeutic use

Arterioles - drug effects

Arterioles - pathology

Blood Pressure - drug effects

Brain - blood supply

Brain - drug effects

Diuretics - administration & dosage

Diuretics - pharmacology

Diuretics - therapeutic use

Dose-Response Relationship, Drug

Hypertension - drug therapy

Hypertension - pathology

Hypertrophy

Indapamide - administration & dosage

Indapamide - pharmacology

Indapamide - therapeutic use

Male

Nitric Oxide - physiology

Rats

Rats, Inbred SHR

Rats, Inbred WKY

Details

Title: Subtitle: Effects of indapamide, a thiazide-like diuretic, on structure of cerebral arterioles in hypertensive rats
Creators: Jean-Marc Chillon - Laboratory of Cardiovascular Pharmacology, Faculty of Pharmacy, University Henri Poincaré-Nancy, France
Gary L Baumbach
Resource Type: Journal article
Publication Details: Hypertension (Dallas, Tex. 1979), Vol.43(5), pp.1092-1097
DOI: 10.1161/01.HYP.0000122874.21730.81
PMID: 15007039
NLM abbreviation: Hypertension
ISSN: 0194-911X
eISSN: 1524-4563
Grant note: HL94-006 / NHLBI NIH HHS HL-22149 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
Language: English
Date published: 05/2004
Academic Unit: Pathology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984186753102771

Metrics

20 Record Views

21 Times Cited - Web of Science