Journal article
Effects of lidocaine injections into the lateral parabrachial nucleus on dipsogenic and pressor responses to central angiotensin II in rats
Brain research, Vol.695(2), pp.250-252
1995
DOI: 10.1016/0006-8993(95)00872-N
PMID: 8556339
Abstract
This study investigated the effects of bilateral injections of the local anesthetic, lidocaine, into the lateral parabrachial nucleus (LPBN) on the dipsogenic and pressor responses induced by intracerebroventricular (i.c.v.) injection of angiotensin II (ANG II). Centrally injected ANG II (50 ng/1 μl) induced water intake (10.2 ± 0.8 ml/h) and pressor responses (22 ± 1mmHg). Prior bilateral injection of 10% lidocaine (200 nl) into the LPBN increased the water intake (14.2 ± 1.4 ml/h), but did not change the pressor response (17 ± 1 mmHg) to i.c.v. ANG II. Lidocaine alone injected into the LPBN also induced a pressor response (23 ± 3 mmHg). These results showing that bilateral LPBN injection of lidocaine increase water intake induced by i.c.v. ANG II are consistent with electrolytic and neurotoxic lesion studies and suggest that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II. These results also provides evidence that it is feasible to reversibly anesthetize this brain area to facilitate fluid-related ingestive behavior.
Details
- Title: Subtitle
- Effects of lidocaine injections into the lateral parabrachial nucleus on dipsogenic and pressor responses to central angiotensin II in rats
- Creators
- Jose Vanderlei Menani - Departments of Psychology and Pharmacology and The Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USATerry G Beltz - Departments of Psychology and Pharmacology and The Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USAAlan Kim Johnson - Departments of Psychology and Pharmacology and The Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USA
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.695(2), pp.250-252
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(95)00872-N
- PMID
- 8556339
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1995
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213268502771
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