Journal article
Effects of life-long fluoride intake on bone measures of adolescents: a prospective cohort study
Journal of dental research, Vol.93(4), pp.353-359
04/2014
DOI: 10.1177/0022034514520708
PMCID: PMC3957342
PMID: 24470542
Abstract
Controversy persists concerning the impact of community water fluoridation on bone health in adults, and few studies have assessed relationships with bone at younger ages. Ecological studies of fluoride's effects showed some increase in bone mineral density of adolescents and young adults in areas with fluoridated water compared with non-fluoridated areas. However, none had individual fluoride exposure measures. To avoid ecological fallacy and reduce bias, we assessed associations of average daily fluoride intake from birth to age 15 yr for Iowa Bone Development Study cohort members with age 15 yr dual-energy x-ray absorptiometry (DXA) bone outcomes (whole body, lumbar spine, and hip), controlling for known determinants (including daily calcium intake, average daily time spent in moderate-to-vigorous intensity physical activity, and physical maturity). Mean (SD) daily fluoride intake was 0.66 mg (0.24) for females and 0.78 mg (0.30) for males. We found no significant relationships between daily fluoride intake and adolescents' bone measures in adjusted models (for 183 females, all p values ≥ .10 and all partial R(2) ≤ 0.02; for 175 males, all p values ≥ .34 and all partial R(2) ≤ 0.01). The findings suggest that fluoride exposures at the typical levels for most US adolescents in fluoridated areas do not have significant effects on bone mineral measures.
Details
- Title: Subtitle
- Effects of life-long fluoride intake on bone measures of adolescents: a prospective cohort study
- Creators
- S M Levy - Department of Preventive & Community Dentistry, University of Iowa College of Dentistry, Iowa City, IA, USAJ J WarrenK PhippsE LetuchyB BroffittJ Eichenberger-GilmoreT L BurnsG KavandK F JanzJ C TornerC A Pauley
- Resource Type
- Journal article
- Publication Details
- Journal of dental research, Vol.93(4), pp.353-359
- DOI
- 10.1177/0022034514520708
- PMID
- 24470542
- PMCID
- PMC3957342
- NLM abbreviation
- J Dent Res
- ISSN
- 0022-0345
- eISSN
- 1544-0591
- Publisher
- United States
- Grant note
- M01-RR00059 / NCRR NIH HHS M01 RR000059 / NCRR NIH HHS R01 DE009551 / NIDCR NIH HHS R01-DE12101 / NIDCR NIH HHS R01-DE09551 / NIDCR NIH HHS UL1 RR024979 / NCRR NIH HHS R01 DE012101 / NIDCR NIH HHS
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Preventive and Community Dentistry; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery; Health, Sport, and Human Physiology
- Record Identifier
- 9983917788602771
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