Effects of local reduction in pressure on endothelium-dependent responses of cerebral arterioles

G L Baumbach; F M Faraci; D D Heistad

doi:10.1161/01.STR.25.7.1456

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Effects of local reduction in pressure on endothelium-dependent responses of cerebral arterioles

Journal article

Open access

Peer reviewed

Effects of local reduction in pressure on endothelium-dependent responses of cerebral arterioles

G L Baumbach, F M Faraci and D D Heistad

Stroke (1970), Vol.25(7), pp.1456-1461

07/1994

DOI: 10.1161/01.STR.25.7.1456

PMID: 8023363

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Abstract

The goal of this study was to examine effects of local reductions in intravascular pressure and dP/dt on endothelium-dependent responses of cerebral arterioles in normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). WKY and SHRSP underwent clipping of one carotid artery at 1 month of age. At 6 months of age, responses of pial arterioles were examined in vivo in anesthetized rats. Bilateral craniotomies were performed to expose pial arterioles in the sham-operated and clipped cerebral hemispheres. Pressure (servo-null) was measured in sham-operated and clipped pial arterioles, and arteriolar diameter was measured before and during suffusion with bradykinin, A23187, and nitroprusside. Carotid clipping normalized pial arteriolar pulse pressure but not mean pressure in SHRSP. Responses of sham-operated pial arterioles to bradykinin and A23187 were less in SHRSP than in WKY. Responses of sham-operated pial arterioles to nitroprusside were greater in SHRSP than in WKY. Carotid clipping in SHRSP normalized responses of pial arterioles to bradykinin but not A23187 and had no effect on responses to nitroprusside. These findings suggest that elevated intravascular pressure per se may contribute to impairment of endothelium-dependent relaxation to at least some agonists in cerebral arterioles during chronic hypertension. Furthermore, the findings lead us to speculate that arteriolar pulse pressure may play a more important role than mean pressure in development of impaired endothelium dilatation during chronic hypertension.

Arterioles - physiology

Blood Pressure

Rats, Inbred SHR

Rats, Wistar

Rats

Endothelium, Vascular - drug effects

Nitroprusside - pharmacology

Calcimycin - pharmacology

Hypertension - physiopathology

Endothelium, Vascular - physiology

Brain - drug effects

Brain - blood supply

Animals

Vasodilation - drug effects

Nitric Oxide - metabolism

Bradykinin - pharmacology

Details

Title: Subtitle: Effects of local reduction in pressure on endothelium-dependent responses of cerebral arterioles
Creators: G L Baumbach - Department of Pathology, University of Iowa College of Medicine, Iowa City 52242
F M Faraci
D D Heistad
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.25(7), pp.1456-1461
DOI: 10.1161/01.STR.25.7.1456
PMID: 8023363
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Publisher: United States
Grant note: HL-16066 / NHLBI NIH HHS HL-22149 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
Language: English
Date published: 07/1994
Academic Unit: Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040308402771

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