Journal article
Effects of locoregional radiotherapy in patients with metastatic breast cancer
Breast (Edinburgh), Vol.28, pp.73-78
08/01/2016
DOI: 10.1016/j.breast.2016.05.001
PMID: 27240169
Abstract
Objectives: This study aims to assess the clinical outcomes of patients with metastatic breast cancer (MBC) who underwent local radiation therapy (RT) for the primary site.
Material and methods: Between 2005 and 2013, we retrospectively evaluated patients with MBC who received breast or chest wall RT with or without regional lymph node irradiation.
Results: 2761 patients with breast cancer were treated with RT. Of them, 125 women with stage IV breast carcinoma were included. The median follow-up was 15 months (ranging from 3.8 to 168 months), when 54.7% of the patients had died; local progression was observed in 22.8% of the patients. The mean overall survival (OS) and local progression free survival (LoPFS) were 23.4 +/- 2.4 months and 45.1 +/- 2.9 months, respectively. Three-and five-year overall survival rates were, respectively, 21.2% and 13.3%. Local progression free survival was the same, 67.3%, at three and five years, respectively. Karnofsky Performance Status (KPS) (p = 0.015), number of metastatic sites (p = 0.031), RT dose (p = 0.0001) and hormone therapy (p = 0.0001) were confirmed as independent significant variables correlated with OS. The variables that were independently correlated with LoPFS were the number of previous chemotherapy lines (p = 0.038) and RT dose (p = 0.0001).
Conclusion: RT of the primary site in patients with MBC is well tolerated. The factors that presented positive impact on survival were good KPS, low disease burden (1-3 metastatic sites), and the use of hormone therapy. (C) 2016 Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- Effects of locoregional radiotherapy in patients with metastatic breast cancer
- Creators
- Geovanne Pedro Mauro - Instituto do Câncer do Estado de São PauloHeloisa de Andrade Carvalho - Univ Sao Paulo, Dept Radiol & Oncol, Inst Radiol, Hosp Clin,Fac Med, Ave Dr Arnaldo 251, BR-01246000 Sao Paulo, SP, BrazilSilva Radwanski Stuart - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloMax Senna Mano - Hospital Sírio-LibanêsGustavo Nader Marta - Hospital Sírio-Libanês
- Resource Type
- Journal article
- Publication Details
- Breast (Edinburgh), Vol.28, pp.73-78
- DOI
- 10.1016/j.breast.2016.05.001
- PMID
- 27240169
- NLM abbreviation
- Breast
- ISSN
- 0960-9776
- eISSN
- 1532-3080
- Publisher
- Elsevier
- Number of pages
- 6
- Language
- English
- Date published
- 08/01/2016
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984914148302771
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