Journal article
Effects of maternal hypertension on cord blood Arginine vasopressin receptor expression
Pregnancy hypertension, Vol.31, pp.1-3
11/18/2022
DOI: 10.1016/j.preghy.2022.11.005
PMCID: PMC9974773
PMID: 36435036
Abstract
Arginine vasopressin (AVP) signaling is altered in preeclampsia and physiologic stress. AVP is implicated in fluid homeostasis and cardiovascular (CV) function, which is disrupted in some progeny from preeclamptic pregnancies. However, whether altered fetal AVP signaling occurs in preeclampsia is unknown. Here, we measured CV-related transcripts (e.g., AVP receptors) in cord blood via quantitative PCR. Chronic hypertension decreased AVPR1b, AVPR2, OXTR, LNPEP, and CUL5. AVPR1a, AVPR1b, and AVPR2 were decreased while OXTR was increased in preeclamptic cord blood. In sum, we found prenatal exposure to hypertension in pregnancy alters fetal AVP signaling and may thereby prime offspring CV disease risk.
Details
- Title: Subtitle
- Effects of maternal hypertension on cord blood Arginine vasopressin receptor expression
- Creators
- Serena Gumusoglu - University of IowaLauren DavisBrandon SchicklingEric DevorLydia Von TerschMark SantillanDonna Santillan
- Resource Type
- Journal article
- Publication Details
- Pregnancy hypertension, Vol.31, pp.1-3
- DOI
- 10.1016/j.preghy.2022.11.005
- PMID
- 36435036
- PMCID
- PMC9974773
- NLM abbreviation
- Pregnancy Hypertens
- eISSN
- 2210-7797
- Language
- English
- Date published
- 11/18/2022
- Academic Unit
- Iowa Neuroscience Institute; Obstetrics and Gynecology
- Record Identifier
- 9984322834602771
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