Journal article
Effects of microgravity on vestibular development and function in rats: Genetics and environment
Korean journal of biological sciences, Vol.4(3), pp.215-221
01/01/2000
DOI: 10.1080/12265071.2000.9647547
PMID: 12760372
Abstract
Our anatomical and behavioral studies of embryonic rats that developed in microgravity suggest that the vestibular sensory system, like the visual system, has genetically mediated processes of development that establish crude connections between the periphery and the brain. Environmental stimuli also regulate connection formation including terminal branch formation and fine-tuning of synaptic contacts. Axons of vestibular sensory neurons from gravistatic as well as linear acceleration receptors reach their targets in both microgravity and normal gravity, suggesting that this is a genetically regulated component of development. However, microgravity exposure delays the development of terminal branches and synapses in gravistatic but not linear acceleration-sensitive neurons and also produces behavioral changes. These latter changes reflect environmentally controlled processes of development.
Details
- Title: Subtitle
- Effects of microgravity on vestibular development and function in rats: Genetics and environment
- Creators
- April E Ronca - Ames Research CenterBernd Fritzsch - Department of Biomedical Sciences , Creighton UniversityJeffrey R Alberts - Indiana UniversityLaura L Bruce - Department of Biomedical Sciences , Creighton University
- Resource Type
- Journal article
- Publication Details
- Korean journal of biological sciences, Vol.4(3), pp.215-221
- DOI
- 10.1080/12265071.2000.9647547
- PMID
- 12760372
- NLM abbreviation
- Korean J Biol Sci
- ISSN
- 1226-5071
- Publisher
- Taylor & Francis Group
- Language
- English
- Date published
- 01/01/2000
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070679502771
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