Effects of naloxone on canine cerebral vascular smooth muscle

Tomio Sasaki; Neal F Kassell; Donn M Turner; William Maixner; James C Torner; Hans C Coester

doi:10.1038/jcbfm.1984.24

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Effects of naloxone on canine cerebral vascular smooth muscle

Journal article

Open access

Peer reviewed

Effects of naloxone on canine cerebral vascular smooth muscle

Tomio Sasaki, Neal F Kassell, Donn M Turner, William Maixner, James C Torner and Hans C Coester

Journal of cerebral blood flow and metabolism, Vol.4(2), pp.166-172

06/1984

DOI: 10.1038/jcbfm.1984.24

PMID: 6725428

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Abstract

The pharmacological effects of naloxone on cerebral arterial smooth muscle in vitro were examined using canine basilar arterial strips. Naloxone exerted two different effects on canine basilar artery: (1) at a high concentration (3 X 10(-4) M) it produced nonspecific vasodilation, and (2) at lower concentrations (3 X 10(-7), 3 X 10(-6), and 3 X 10(-5) M) it inhibited the vasoconstrictor effects of norepinephrine without altering KCl-, serotonin-, or hemoglobin-induced constriction. Morphine (2 X 10(-5) or 2 X 10(-4) M) did not reverse the specific vasodilating effect of naloxone (3 X 10(-5) M) on norepinephrine-induced constriction. Rather, morphine and naloxone together produced a greater vasodilating effect on norepinephrine-induced constriction than either agent alone. Naloxone (3 X 10(-5) M) failed to alter either phenylephrine-induced constriction or clonidine-induced constriction. The vasodilating effect of naloxone (3 X 10(-5) M) on 10(-3) M norepinephrine-induced constriction was not reduced with 10(-6) M propranolol. These results suggest that the vasodilating effect of naloxone on norepinephrine-induced constriction does not result from an antagonistic action on opiate receptors, direct inhibition of alpha-adrenoreceptors, or direct stimulation of beta-adrenoreceptors in canine cerebral arterial smooth muscle. The vasodilating effect of naloxone on norepinephrine-induced constriction may influence the CBF changes following naloxone administration.

Norepinephrine - pharmacology

Basilar Artery - drug effects

Male

Serotonin - pharmacology

Vasoconstriction - drug effects

Animals

Receptors, Adrenergic - drug effects

Naloxone - pharmacology

Potassium Chloride - pharmacology

Dogs

Female

Basilar Artery - physiology

Hemoglobins - pharmacology

Vasodilation - drug effects

Epinephrine - pharmacology

Muscle, Smooth, Vascular - drug effects

Details

Title: Subtitle: Effects of naloxone on canine cerebral vascular smooth muscle
Creators: Tomio Sasaki
Neal F Kassell
Donn M Turner
William Maixner
James C Torner
Hans C Coester
Resource Type: Journal article
Publication Details: Journal of cerebral blood flow and metabolism, Vol.4(2), pp.166-172
DOI: 10.1038/jcbfm.1984.24
PMID: 6725428
NLM abbreviation: J Cereb Blood Flow Metab
ISSN: 0271-678X
eISSN: 1559-7016
Publisher: United States
Language: English
Date published: 06/1984
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995106102771

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