Journal article
Effects of neonatal lung abnormalities on parenchymal R 2 estimates
Journal of magnetic resonance imaging, Vol.53(6), pp.1853-1861
06/2021
DOI: 10.1002/jmri.27487
PMCID: PMC8915922
PMID: 33404085
Abstract
Infants admitted to the neonatal intensive care unit (NICU) often suffer from multifaceted pulmonary morbidities that are not well understood. Ultrashort echo time (UTE) magnetic resonance imaging (MRI) is a promising technique for pulmonary imaging in this population without requiring exposure to ionizing radiation. The aims of this study were to investigate the effect of neonatal pulmonary disease on R
* and tissue density and to utilize numerical simulations to evaluate the effect of different alveolar structures on predicted R
*.This was a prospective study, in which 17 neonatal human subjects (five control, seven with bronchopulmonary dysplasia [BPD], five with congenital diaphragmatic hernia [CDH]) were enrolled. Twelve subjects were male and five were female, with postmenstrual age (PMA) at MRI of 39.7 ± 4.7 weeks. A 1.5T/multiecho three-dimensional UTE MRI was used. Pulmonary R
* and tissue density were compared across disease groups over the whole lung and regionally. A spherical shell alveolar model was used to predict the expected R
* over a range of tissue densities and tissue susceptibilities. Tests for significantly different mean R
* and tissue densities across disease groups were evaluated using analysis of variance, with subsequent pairwise group comparisons performed using t tests. Lung tissue density was lower in the ipsilateral lung in CDH compared to both controls and BPD patients (both p < 0.05), while only the contralateral lung in CDH (CDHc) had higher whole-lung R
* than both controls and BPD (both p < 0.05). R
* differences were significant between controls and CDHc within all tissue density ranges (all p < 0.05) with the exception of the 80%-90% range (p = 0.17). Simulations predicted an inverse relationship between alveolar tissue density and R
* that matches empirical human data. Alveolar wall thickness had no effect on R
* independent of density (p = 1). The inverse relationship between R
* and tissue density is influenced by the presence of disease globally and regionally in neonates with BPD and CDH in the NICU. LEVEL OF EVIDENCE: 2. TECHNICAL EFFICACY STAGE: 2.
Details
- Title: Subtitle
- Effects of neonatal lung abnormalities on parenchymal R 2 estimates
- Creators
- Andrew D Hahn - University of Wisconsin–MadisonAnnelise Malkus - University of Wisconsin–MadisonJeffery Kammerman - University of Wisconsin–MadisonNara Higano - Cincinnati Children's Hospital Medical CenterLaura L Walkup - Cincinnati Children's Hospital Medical CenterJason Woods - Cincinnati Children's Hospital Medical CenterSean B Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.53(6), pp.1853-1861
- DOI
- 10.1002/jmri.27487
- PMID
- 33404085
- PMCID
- PMC8915922
- NLM abbreviation
- J Magn Reson Imaging
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Grant note
- T32 HL007752 / NHLBI NIH HHS R01 HL126771 / NHLBI NIH HHS R01 HL146689 / NHLBI NIH HHS T32 CA009206 / NCI NIH HHS T32 HL0007752 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275055102771
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