Journal article
Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation
Seminars in cell & developmental biology, Vol.8(3), pp.277-284
06/1997
DOI: 10.1006/scdb.1997.0144
PMID: 10024490
Abstract
Two neurotrophins and their two receptors appear to regulate the survival of vestibular and cochlear neurons in the developing ear. Mice lacking either brain derived neurotrophic factor (BDNF) or its associated receptor, Trk B, show a severe reduction in the number of vestibular neurons and a loss of all innervation to the semicircular canals. Mice lacking NT-3 or its receptor, Trk C, show a severe reduction of spiral neurons in the basal turn of the cochlea. Mice lacking both BDNF and NT-3 or Trk B and Trk C, reportedly lose all innervation to the inner ear. These two neurotrophins and their associated receptors are necessary for the normal afferent innervation of the inner ear.
Details
- Title: Subtitle
- Effects of neurotrophin and neurotrophin receptor disruption on the afferent inner ear innervation
- Creators
- B Fritzsch - Department of Biomedical Sciences, Creighton University, Omaha, NE, 68178I Silos-Santiago - Department of Molecular Oncology, Bristol-Meyers Squibb, Princeton, NJ, 08543L.M Bianchi - Department of Otolaryngology, Medical University of South Carolina, Charleston, SC, 29425I Fariñas - Howard Hughes Medical Institute, UCLA, San Francisco, CA, 94143, USA
- Resource Type
- Journal article
- Publication Details
- Seminars in cell & developmental biology, Vol.8(3), pp.277-284
- DOI
- 10.1006/scdb.1997.0144
- PMID
- 10024490
- NLM abbreviation
- Semin Cell Dev Biol
- ISSN
- 1084-9521
- eISSN
- 1096-3634
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 06/1997
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070599702771
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