Journal article
Effects of nicotine and tobacco‐specific nitrosamines on hamster cheek pouch and gastric mucosa
Journal of oral pathology & medicine, Vol.23(6), pp.251-255
07/1994
DOI: 10.1111/j.1600-0714.1994.tb00054.x
PMID: 7932244
Abstract
Fifty‐two hamsters were divided into 6 groups and their cheek pouches treated with either 0.01% NNN, 0.01% NNN and 6% nicotine, 0.01%. NNK, 0.01% NNK and 6% nicotine, 6%i nicotine, or sesame oil. After painting each pouch 3 times per week for 13 months, the animals were killed and specimens from the cheek pouch and forestomach examined. Cheek pouch epithelium showed more frequent histologic changes, including hyperplasia, hyperkeratosis and, in one animal, moderate dysplasia, when nicotine was combined with NNN than after treatment with NNN (or nicotine) alone. There was a higher frequency of hyperplasia with hyperkeratosis in the forestomach when nicotine was combined with NNK than following NNK, or nicotine treatment alone, and squamous cell papillomas were evident in animals treated with both NNK and nicotine. These results suggest that in mucosal tissues nicotine may enhance the effect of weak carcinogens such as the nitrosamines.
Details
- Title: Subtitle
- Effects of nicotine and tobacco‐specific nitrosamines on hamster cheek pouch and gastric mucosa
- Creators
- Y‐P ChenG. K JohnsonC. A Squier
- Resource Type
- Journal article
- Publication Details
- Journal of oral pathology & medicine, Vol.23(6), pp.251-255
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1111/j.1600-0714.1994.tb00054.x
- PMID
- 7932244
- ISSN
- 0904-2512
- eISSN
- 1600-0714
- Number of pages
- 5
- Language
- English
- Date published
- 07/1994
- Academic Unit
- Oral Pathology, Radiology and Medicine; International Programs; Periodontics
- Record Identifier
- 9984065715502771
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