Journal article
Effects of occupational exposure to styrene on expression of adhesion molecule on leukocytes
Human & experimental toxicology, Vol.21(5), pp.235-240
2002
DOI: 10.1191/0960327102ht251oa
PMID: 12141393
Abstract
Styrene is an indispensable chemical extensively used in plastic and synthetic rubber industries. Styrene is known to produce various types of hepatotoxic, neurotoxic, and genotoxic effects. Styrene may be immunotoxic by both direct and indirect mechanisms. Measurement of adhesion molecules is a new tool for the investigation of immune system modulation. The aim of this study was to evaluate the association of the expression of the adhesion molecules CD11a, CD11b, CD18, CD54, CD49d, and CD62-L in white blood cells and levels of soluble adhesion molecules ICAM-1 and L-selectin in serum with occupational exposure to styrene. Analyses by flow cytometry revealed elevated levels of most of the assessed adhesion molecules on surfaces of lymphocytes, monocytes, and granulocytes. Expression of the adhesion receptor antigens CD11a on lymphocytes, CD11b on monocytes, and CD18 on granulocytes were unaffected. Workers exposed to styrene had decreased concentrations of sICAM-1 and no changes in concentrations of sL-selectin. Styrene exposure appears to increase activation of the immune system and alter leukocyte adherence. This interaction is a critical first step in immune stimulation and leukocyte-endothelial interaction.
Details
- Title: Subtitle
- Effects of occupational exposure to styrene on expression of adhesion molecule on leukocytes
- Creators
- E Jahnova - Slovak Medical UniversityJ Tulinska - Institute of Preventive and Clinical Medicine, Limbová 14, 833 01 Bratislava, SlovakiaS Weissova - Institute of Preventive and Clinical Medicine, Limbová 14, 833 01 Bratislava, SlovakiaM Dusinska - Slovak Medical UniversityL Fuortes - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Human & experimental toxicology, Vol.21(5), pp.235-240
- Publisher
- Arnold
- DOI
- 10.1191/0960327102ht251oa
- PMID
- 12141393
- ISSN
- 0960-3271
- eISSN
- 1477-0903
- Language
- English
- Date published
- 2002
- Academic Unit
- Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984364419302771
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