Journal article
Effects of pioglitazone or exercise in older adults with mild cognitive impairment and insulin resistance: a pilot study
Dementia and geriatric cognitive disorders extra, Vol.5(1), pp.51-63
01/2015
DOI: 10.1159/000371509
PMCID: PMC4361908
PMID: 25852732
Abstract
To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance.
Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endurance exercise, pioglitazone or control.
Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control.
In this pilot study, pioglitazone improved insulin resistance but not cognitive performance in older adults with MCI and insulin resistance.
Details
- Title: Subtitle
- Effects of pioglitazone or exercise in older adults with mild cognitive impairment and insulin resistance: a pilot study
- Creators
- Kerry L Hildreth - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USARachael E Van Pelt - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAKerrie L Moreau - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAJim Grigsby - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAKarin F Hoth - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAVictoria Pelak - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAC Alan Anderson - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USABennett Parnes - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAJohn Kittelson - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAPamela Wolfe - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USATammie Nakamura - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USASunny A Linnebur - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAJennifer M Trujillo - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USAChristina L Aquilante - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USARobert S Schwartz - Division of Geriatric Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., USA
- Resource Type
- Journal article
- Publication Details
- Dementia and geriatric cognitive disorders extra, Vol.5(1), pp.51-63
- DOI
- 10.1159/000371509
- PMID
- 25852732
- PMCID
- PMC4361908
- NLM abbreviation
- Dement Geriatr Cogn Dis Extra
- ISSN
- 1664-5464
- eISSN
- 1664-5464
- Publisher
- Switzerland
- Grant note
- UL1 TR001082 / NCATS NIH HHS R01 AG028746 / NIA NIH HHS R01 DK088105 / NIDDK NIH HHS K23 AG045201 / NIA NIH HHS T32 AG000279 / NIA NIH HHS
- Language
- English
- Date published
- 01/2015
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984066147302771
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