Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preference

K. Matthew LATTAL; Shaya HONARVAR; Ted ABEL

doi:10.1016/j.bbr.2003.12.009

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Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preference

Journal article

Peer reviewed

Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preference

K. Matthew LATTAL, Shaya HONARVAR and Ted ABEL

Behavioural brain research, Vol.153(2), pp.327-339

2004

DOI: 10.1016/j.bbr.2003.12.009

PMID: 15265627

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Abstract

Four experiments with C57BL/6 mice examined the effects of protein synthesis inhibition on extinction of spatial preferences in the Morris water maze. The protein synthesis inhibitor anisomycin was injected systemically immediately after spatial reversal sessions, which consisted of eight, two, or one reversal trials. Anisomycin had no effect on extinction of a spatial preference with eight reversal trials per session. When only two reversal trials were administered per session, anisomycin slowed extinction initially, although full extinction occurred with further training even in the presence of anisomycin. In both cases, anisomycin blocked acquisition of the reversal preference. When anisomycin injections followed a single simple extinction trial, performance was not disrupted. These findings suggest that acquisition and extinction may involve different molecular processes, and they do not support the idea that brief extinction trials induce a protein synthesis-dependent reconsolidation phase of spatial memory.

Fundamental and applied biological sciences. Psychology

Learning

Behavioral psychophysiology

Psychology. Psychoanalysis. Psychiatry

Anatomical correlates of behavior

Animal

Psychology. Psychophysiology

Biological and medical sciences

Learning. Memory

Details

Title: Subtitle: Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preference
Creators: K. Matthew LATTAL - Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, United States
Shaya HONARVAR - Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, United States
Ted ABEL - Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, United States
Resource Type: Journal article
Publication Details: Behavioural brain research, Vol.153(2), pp.327-339
Publisher: Elsevier Science; Shannon
DOI: 10.1016/j.bbr.2003.12.009
PMID: 15265627
ISSN: 0166-4328
eISSN: 1872-7549
Language: English
Date published: 2004
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984065828402771

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