Journal article
Effects of prenatal exposure to ambient air pollutant PM10 on ultrasound-measured fetal growth
International journal of epidemiology, Vol.47(4), pp.1072-1081
08/01/2018
DOI: 10.1093/ije/dyy019
PMCID: PMC6124630
PMID: 29529195
Abstract
Background: Limited epidemiological studies have investigated the relationship between prenatal exposure to ambient particulate matter and risk of abnormal fetal growth, and have reached inconclusive results. No study has been conducted in areas with very high air pollution levels. We investigated the hypothesis that exposure to high levels of particulate matter with aerodynamic diameter no larger than 10 mm (PM10) during pregnancy increases the risk of abnormal fetal growth.
Methods: A birth cohort study was performed in Lanzhou, China, 2010-12, including 8877 pregnant women with 18 583 ultrasound measurements of four fetal growth parameters during pregnancy, including biparietal diameter (BPD), femur length (FL), head circumference (HC) and abdominal circumference (AC). Mixed-effects modelling was used to examine the associations between PM10 exposure and risk of abnormal fetal growth.
Results: When average PM10 exposure from conception until the ultrasound examination exceeded 150 mu g/m(3), there were significant increases in standardized FL (beta = 0.095, P = 0.0012) and HC (beta = 0.090, P = 0.0078) measures. When average PM10 exposure was treated as continuous variable, we found a significant decrease in standardized BPD (beta = -0.018, P = 0.0016) as per 10 mu g/m(3) increase in PM10. After examining the associations by various exposure windows, positive associations between higher levels of PM10 and fetal overgrowth were consistently seen for HC measures.
Conclusions: Our study suggested that prenatal exposure to high levels of ambient PM10 increased the risk of abnormal fetal growth. The findings from our study have important public health implications and also call for future studies to explore the underlying mechanisms and post-natal consequences of these findings.
Details
- Title: Subtitle
- Effects of prenatal exposure to ambient air pollutant PM10 on ultrasound-measured fetal growth
- Creators
- Nan Zhao - Yale UniversityJie Qiu - Gansu Provincial Maternal and Child Health HospitalShuangge Ma - Yale UniversityYaqun Zhang - Gansu Academy of SciencesXiaojuan Lin - Gansu Provincial Maternal and Child Health HospitalZhongfeng Tang - Gansu Provincial Maternal and Child Health HospitalHonghong Zhang - Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R ChinaHuang Huang - Yale UniversityNing Ma - Beijing Children’s HospitalYuan Huang - Yale UniversityMichelle L. Bell - Yale UniversityQing Liu - Gansu Provincial Maternal and Child Health HospitalYawei Zhang - Yale University
- Resource Type
- Journal article
- Publication Details
- International journal of epidemiology, Vol.47(4), pp.1072-1081
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/ije/dyy019
- PMID
- 29529195
- PMCID
- PMC6124630
- ISSN
- 0300-5771
- eISSN
- 1464-3685
- Number of pages
- 10
- Grant note
- Gansu Provincial Maternity and Child Care Hospital 1204WCGA021 / Gansu Provincial Science and Technology Department Grant EPA-G2014-STAR-J1 / U.S. Environmental Protection Agency; United States Environmental Protection Agency K02HD70324; R01ES019587 / National Institutes of Health Grants; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 08/01/2018
- Academic Unit
- Biostatistics
- Record Identifier
- 9984363643202771
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