Journal article
Effects of prototypic PCBs on benzo[ a]pyrene mutagenic activity related to vitamin A intake
Mutation research, Vol.211(1), pp.139-145
1989
DOI: 10.1016/0027-5107(89)90114-0
PMID: 2493575
Abstract
The effects of vitamin A dietary intake (2 and 20 IU
∗/g of food) on the mutagenic activity of benzo[
a]pyrene (B(a)P) toward
Salmonella typhimurium (TA98) were studied either in control rats or in animals treated by the PCB congeners 2,4,5,2′,4′,5′-hexachlorobiphenyl ((2,4,5)
2Cl) and 3,4,3′,4′-tetrachlorobiphenyl ((3,4)
2Cl). (3,4)
2Cl (a planar compound) strongly increased B(a)P monooxygenase (B(a)PMO) activity and glutathione transferase, (2,4,5)
2Cl (a non-planar PCB) was a strong inducer of epoxide hydrolase and a weak inducer of B(a)PMO. Enzyme induction was not modified by changes in vitamin A dietary intake. A higher mutagenic effect was observed in the (3,4)
2Cl group than in the (2,4,5)
2Cl one. This could be related to the specific form of cytochrome P-450 induced by (3,4)
2Cl. In the untreated animals, the activation of B(a)P was higher in the 2-IU group than in the 20-IU one. Conversely, in PCB-treated rats the mutagenic activity of B(a)P was higher in the 20-IU group than in the 2-IU one. PCB induction increased the liver content of vitamin C in both the 2-IU and the 20-IU groups but only increased the glutathione levels in the 2-IU groups. This suggests that glutathione content in cellular fractions may be one of the determining parameters for the mutagenic activity of B(a)P.
Details
- Title: Subtitle
- Effects of prototypic PCBs on benzo[ a]pyrene mutagenic activity related to vitamin A intake
- Creators
- P Grolier - Réseau Toxicologie Nutritionelle MRES, Université de Bordeaux I, 33405 Talence Cedex FranceP Cassand - Réseau Toxicologie Nutritionelle MRES, Université de Bordeaux I, 33405 Talence Cedex FranceE Antignac - Réseau Toxicologie Nutritionelle MRES, Université de Bordeaux I, 33405 Talence Cedex FranceJ.F Narbonne - Laboratoire de Toxicologie Nutritionelle, Université de Bordeaux I, 33405 Talence Cedex FranceR Albrecht - Laboratoire de Biologie CNAM, 75003 Paris FranceV Azais - Station de Recherches de Nutrition, INRA, CRNZ, 78350, Jouy-en-Josas FranceL.W Robertson - Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40506-0054 U.S.AF Oesch - Institut für Toxikologie, Universität Mainz, D-65000 Mainz F.R.G
- Resource Type
- Journal article
- Publication Details
- Mutation research, Vol.211(1), pp.139-145
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0027-5107(89)90114-0
- PMID
- 2493575
- ISSN
- 0027-5107
- eISSN
- 1873-135X
- Language
- English
- Date published
- 1989
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002595302771
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