Journal article
Effects of quinidine on venous responses to adrenergic and nonadrenergic constrictor stimuli: indirect evidence of two sites of action in vascular smooth muscle
Proceedings of the Society for Experimental Biology and Medicine, Vol.146(2), pp.409-413
06/1974
DOI: 10.3181/00379727-146-38116
PMID: 4834451
Abstract
The effect of quinidine on adrenergic and nonadrenergic constrictor stimuli was studied in the perfused canine saphenous vein. Quinidine significantly reduced constrictor responses to sympathetic nerve stimulation, phenylephrine and norepinephrine while responses to a nonadrenergic constrictor drug, 5-hydroxytryptamine, were not reduced, indicating that quinidine interferes with stimuli that activate alpha adrenergic receptors. Quinidine also had a smaller yet significant effect on constrictor response to KCl suggesting a possible second site of action.
Details
- Title: Subtitle
- Effects of quinidine on venous responses to adrenergic and nonadrenergic constrictor stimuli: indirect evidence of two sites of action in vascular smooth muscle
- Creators
- Loren D NelsonPhillip G SchmidDavid HolmstenAllyn L MarkDonald D HeistadFrancois M Abboud
- Resource Type
- Journal article
- Publication Details
- Proceedings of the Society for Experimental Biology and Medicine, Vol.146(2), pp.409-413
- Publisher
- United States
- DOI
- 10.3181/00379727-146-38116
- PMID
- 4834451
- ISSN
- 0037-9727
- eISSN
- 1525-1373
- Language
- English
- Date published
- 06/1974
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Pharmacy Practice and Science; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025581102771
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