Journal article
Effects of reflex stimuli on blood flow to the adrenal medulla
American journal of physiology. Heart and circulatory physiology, Vol.257(2), pp.H590-H596
08/01/1989
DOI: 10.1152/ajpheart.1989.257.2.H590
PMID: 2764139
Abstract
The goal of this study was to examine changes in blood flow to the adrenal medulla during reflex stimuli that release catecholamines. Adrenal blood flow was measured with microspheres during exercise in conscious dogs and during bicuculline-induced seizures in anesthetized dogs. In awake dogs, blood flow to the adrenal cortex and adrenal medulla was 310 +/- 48 and 1,613 +/- 258 (SE) ml.min-1.100 g-1, respectively. Blood flow to the cortex and medulla was not affected by moderate exercise. Anesthesia (pentobarbital sodium) reduced blood flow to the adrenal cortex and medulla to 158 +/- 12 and 243 +/- 24 ml.min-1.100 g-1, respectively. In anesthetized dogs, seizures markedly increased blood flow to the adrenal medulla (282 +/- 68 to 1,257 +/- 128 ml.min-1.100 g-1), and this response was blocked by sectioning the greater splanchnic nerve. Vasodilator responses of the adrenal medulla to adenosine were not impaired by adrenal denervation. Blood flow to the adrenal cortex was not affected by seizures but increased in response to intravenous adenosine. These findings suggest that 1) anesthesia decreases adrenal blood flow, particularly to the adrenal medulla, and 2) reflex stimuli that release catecholamines can produce selective increases in blood flow to the adrenal medulla.
Details
- Title: Subtitle
- Effects of reflex stimuli on blood flow to the adrenal medulla
- Creators
- Frank M Faraci - Department of Internal Medicine, University of Iowa College ofMedicine, Iowa City 52242William M Chilian - Department of Internal Medicine, University of Iowa College ofMedicine, Iowa City 52242J Koudy Williams - Department of Internal Medicine, University of Iowa College ofMedicine, Iowa City 52242Donald D Heistad - Department of Internal Medicine, University of Iowa College ofMedicine, Iowa City 52242
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.257(2), pp.H590-H596
- DOI
- 10.1152/ajpheart.1989.257.2.H590
- PMID
- 2764139
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 08/01/1989
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040311502771
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