Journal article
Effects of short term metformin administration on androgens in diabetic men
Saudi medical journal, Vol.25(1), pp.75-78
2004
PMID: 14758385
Abstract
Objective: Metformin, an oral hypoglycemic agent, has several other metabolic and hormonal effects. This study aims at identifying the metabolic effect of metformin on androgens in diabetic men.
Methods: The study was conducted at The National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan from April 2001 to September 2001. We studied 15 men with type 2 diabetes mellitus by measuring fasting serum glucose, insulin, glycosylated hemoglobin, total and free testosterone, sex hormone binding globulin, dehydroepiandrosterone sulphate, 17-OH progesterone, luteinizing hormone, and follicle stimulating hormone before and after a short course of metformin.
Results: There was a significant decrease in fasting serum glucose and glycosylated hemoglobin and increase in the level of 17-OH progesterone. The remainder of the measured parameters did not show any significant change. Although serum glucose and glycosylated hemoglobin decreased insulin levels were not changed.
Conclusion: In contrast to normal men there was no change in androgen levels in diabetics but the 17-OH progesterone was elevated.
Details
- Title: Subtitle
- Effects of short term metformin administration on androgens in diabetic men
- Creators
- Nadima S SHEGEM - National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, JapanAbeer M ALSHEEK NASIR - National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, JapanAnwar M BATIEHA - Department of Public Health, College of Medicine, Jordan University of Science and Technology, Amman, JordanHatem EL-SHANTI - Department of Pediatrics, College of Medicine, Jordan University of Science and Technology, Amman, JordanKamel M AJLOUNI - National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Japan
- Resource Type
- Journal article
- Publication Details
- Saudi medical journal, Vol.25(1), pp.75-78
- Publisher
- Saudi Medical Journal
- PMID
- 14758385
- ISSN
- 0379-5284
- Language
- English
- Date published
- 2004
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984093600102771
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