Effects of sinoaortic baroreceptor denervation on depletion-induced salt appetite

R L Thunhorst; S J Lewis; A K Johnson

doi:10.1152/ajpregu.1994.267.4.r1043

Back

Journal article

Effects of sinoaortic baroreceptor denervation on depletion-induced salt appetite

R L Thunhorst, S J Lewis and A K Johnson

American journal of physiology. Regulatory, integrative, and comparative physiology, Vol.267(4 Pt 2), pp.R1043-1049

10/1994

DOI: 10.1152/ajpregu.1994.267.4.r1043

PMID: 7943414

View Online

Abstract

This study examined the effects of denervation of the carotid sinus and aortic arch baroreceptors on sodium depletion-induced salt appetite in rats. Depletion of extracellular fluid began with two injections of furosemide (10 mg/kg sc), 30 min apart, and removal of all ambient sodium from the cages. Water and sodium-deficient chow were available overnight. The next morning, access to 0.3 M NaCl was provided, and intakes of water and saline were measured every 30 min for 2 h and again at 24 h. Three such tests were administered. Groups of sham and sinoaortic baroreceptor-denervated (SAD) rats had equivalently negative water and sodium balances before access to saline the next morning. Sham-denervated rats drank sufficient saline in 2 h to achieve positive sodium balance and subsequently ingested sodium in excess of need for another 22 h. SAD rats drank half as much saline as sham-denervated rats by 2 and 24 h and remained in negative balance at 2 h. Sham-denervated rats increased their intakes of saline solution with repeated tests, but SAD rats did not. These findings suggest that arterial baroreceptors provide critical neural input for the normal expression of salt appetite.

Animals

Aorta, Thoracic - physiology

Appetite - drug effects

Appetite - physiology

Baroreflex - physiology

Blood Pressure - drug effects

Carotid Sinus - physiology

Denervation

Furosemide - pharmacology

Heart Rate - drug effects

Male

Nitroprusside - pharmacology

Phenylephrine - pharmacology

Pressoreceptors - physiology

Rats

Rats, Sprague-Dawley

Reference Values

Sinoatrial Node - drug effects

Sinoatrial Node - physiology

Sodium, Dietary

Details

Title: Subtitle: Effects of sinoaortic baroreceptor denervation on depletion-induced salt appetite
Creators: R L Thunhorst - Department of Psychology, University of Iowa, Iowa City 52242
S J Lewis
A K Johnson
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative, and comparative physiology, Vol.267(4 Pt 2), pp.R1043-1049
DOI: 10.1152/ajpregu.1994.267.4.r1043
PMID: 7943414
ISSN: 0363-6119
eISSN: 1522-1490
Grant note: HL-14338 / NHLBI NIH HHS HL-44546 / NHLBI NIH HHS
Language: English
Date published: 10/1994
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
Record Identifier: 9984213273202771

Metrics

6 Record Views