Effects of sleep deprivation and aging on long-term and remote memory in mice

Christopher G Vecsey; Alan J Park; Nora Khatib; Ted Abel

doi:10.1101/lm.036590.114

Back

Effects of sleep deprivation and aging on long-term and remote memory in mice

Journal article

Open access

Peer reviewed

Effects of sleep deprivation and aging on long-term and remote memory in mice

Christopher G Vecsey, Alan J Park, Nora Khatib and Ted Abel

Learning & memory (Cold Spring Harbor, N.Y.), Vol.22(4), pp.197-202

04/2015

DOI: 10.1101/lm.036590.114

PMCID: PMC4371173

PMID: 25776037

Files and links (1)

url

https://doi.org/10.1101/lm.036590.114View

Published (Version of record) Open Access

Abstract

Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a month after training, sleep-deprived and control aged animals performed similarly, primarily due to remote memory decay in the control aged animals. Gene expression analysis supported the finding that SD has similar effects on the hippocampus in young and aged mice.

Neuropsychological Tests

Memory Disorders - physiopathology

Gene Expression

Sleep Deprivation - physiopathology

Animals

Aging - physiology

Time Factors

Mice, Inbred C57BL

Sleep Deprivation - psychology

Male

Memory, Long-Term - physiology

Details

Title: Subtitle: Effects of sleep deprivation and aging on long-term and remote memory in mice
Creators: Christopher G Vecsey - Department of Biology, Swarthmore College, Swarthmore, Pennsylvania, USA Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Alan J Park - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nora Khatib - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Ted Abel - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA abele@sas.upenn.edu
Resource Type: Journal article
Publication Details: Learning & memory (Cold Spring Harbor, N.Y.), Vol.22(4), pp.197-202
DOI: 10.1101/lm.036590.114
PMID: 25776037
PMCID: PMC4371173
NLM abbreviation: Learn Mem
ISSN: 1072-0502
eISSN: 1549-5485
Publisher: United States
Grant note: P01 AG017628 / NIA NIH HHS HL07953 / NHLBI NIH HHS P50 AG 017628 / NIA NIH HHS T32 GM007517 / NIGMS NIH HHS GM07517 / NIGMS NIH HHS R01 MH099544 / NIMH NIH HHS T32 HL007953 / NHLBI NIH HHS R01 MH 099544 / NIMH NIH HHS
Language: English
Date published: 04/2015
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984065832602771

Metrics

24 Record Views

20 Times Cited - Web of Science