Effects of smoking and preeclampsia on birth weight for gestational age

Cassandra N Spracklen; Kelli K Ryckman; Karisa Harland; Audrey F Saftlas

doi:10.3109/14767058.2014.928853

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Effects of smoking and preeclampsia on birth weight for gestational age

Journal article

Open access

Peer reviewed

Effects of smoking and preeclampsia on birth weight for gestational age

Cassandra N Spracklen, Kelli K Ryckman, Karisa Harland and Audrey F Saftlas

The Journal of Maternal-Fetal & Neonatal Medicine, Vol.28(6), pp.679-684

04/13/2015

DOI: 10.3109/14767058.2014.928853

PMCID: PMC4631401

PMID: 24893615

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https://www.ncbi.nlm.nih.gov/pmc/articles/4631401View

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Abstract

Objective: A counterintuitive interaction between smoking during pregnancy and preeclampsia on birth weight for gestational age (BWGA) outcomes was recently reported. In this report, we examine the relationship between these factors in a well-documented study population with exposure data on trimester of maternal smoking. Methods: Preeclamptic (n = 238), gestational hypertensive (n = 219), and normotensive women (n = 342) were selected from live-births to nulliparous Iowa women. Disease status was verified by medical chart review, and smoking exposure was assessed by self-report. Fetal growth was assessed as z-score of BWGA. Multiple linear regression was used to test for the association of maternal smoking and preeclampsia with BWGA z-score. Results: There was no interaction between smoking with preeclampsia or gestational hypertension on fetal growth. BWGA z-scores were significantly lower among women with preeclampsia and those who smoked any time during pregnancy (β = −0.33, p = <0.0001 and β = −0.25, p = 0.05) compared to normotensive and non-smoking women, respectively. Infants of women with gestational hypertension were comparable in size to infants born to normotensive women. Conclusions: Women who developed preeclampsia and those who smoked during pregnancy delivered infants that were significantly smaller than infants of women who did not develop preeclampsia and non-smoking women, respectively.

z-score

low birth weight

fetal growth

Epidemiology

pregnancy

Details

Title: Subtitle: Effects of smoking and preeclampsia on birth weight for gestational age
Creators: Cassandra N Spracklen - Department of Epidemiology, University of Iowa College of Public Health
Kelli K Ryckman - Department of Epidemiology, University of Iowa College of Public Health
Karisa Harland - Department of Emergency Medicine, University of Iowa
Audrey F Saftlas - Department of Epidemiology, University of Iowa College of Public Health
Resource Type: Journal article
Publication Details: The Journal of Maternal-Fetal & Neonatal Medicine, Vol.28(6), pp.679-684
DOI: 10.3109/14767058.2014.928853
PMID: 24893615
PMCID: PMC4631401
NLM abbreviation: J Matern Fetal Neonatal Med
ISSN: 1476-7058
eISSN: 1476-4954
Publisher: Informa Healthcare
Language: English
Date published: 04/13/2015
Academic Unit: Stead Family Department of Pediatrics; Epidemiology; Emergency Medicine; Injury Prevention Research Center; Public Policy Center (Archive); Law Faculty
Record Identifier: 9983995174502771

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