Journal article
Effects of statins on kidney function in older adults
Journal of the American Geriatrics Society (JAGS), Vol.73(4), pp.1082-1093
04/2025
DOI: 10.1111/jgs.19319
PMCID: PMC11970218
PMID: 39696786
Appears in UI Libraries Support Open Access
Abstract
The effect of statin therapy on kidney function among older adults is unclear.
To examine the association between statin use and changes in estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR), positive or negative, in an older adult cohort with versus without chronic kidney disease (CKD) at baseline.
This analysis included 18,056 participants aged ≥65 years with versus without CKD at baseline in a randomized trial of low-dose aspirin, who had no prior cardiovascular events, major physical disability, or dementia initially. Outcome measures included eGFR and UACR. Linear mixed-effects models were used to estimate the associations of baseline statin use versus no use with eGFR and UACR changes over time. The inverse-probability of treatment-weighting technique was used for all analyses to address confounding by indication due to the lack of randomization in treatment assignment.
Statin use was not associated with change in eGFR, UACR, or incident CKD in participants with or without CKD at baseline (p > 0.05 for all associations). Subgroup analyses found no significant interactions between statin and age, sex, diabetes, country, and frailty status on any of the study outcomes.
Among adults ≥65 years of age, with and without CKD, statin therapy was not associated with improved or worsened kidney function. This data suggests that the decision to use versus not use statins in this population may be ideally guided by factors other than kidney health.
Details
- Title: Subtitle
- Effects of statins on kidney function in older adults
- Creators
- Michelle A Fravel - University of IowaMichael E Ernst - University of IowaRobyn L Woods - Monash UniversitySuzanne G Orchard - Monash UniversityKevan R Polkinghorne - Monash UniversityRory Wolfe - Monash UniversityJames B Wetmore - Hennepin Healthcare Research InstituteMark R Nelson - University of TasmaniaElisa Bongetti - Monash HealthAnne M Murray - Hennepin Healthcare Research InstituteSophia Zoungas - Monash UniversityZhen Zhou - Monash University
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.73(4), pp.1082-1093
- DOI
- 10.1111/jgs.19319
- PMID
- 39696786
- PMCID
- PMC11970218
- NLM abbreviation
- J Am Geriatr Soc
- ISSN
- 1532-5415
- eISSN
- 1532-5415
- Publisher
- Wiley
- Grant note
- NIA NIH HHS 334047 / National Health and Medical Research Council U19AG062682 / NCI NIH HHS U01AG029824 / NCI NIH HHS the Victorian Cancer Agency 1127060 / National Health and Medical Research Council Monash University
- Language
- English
- Electronic publication date
- 12/18/2024
- Date published
- 04/2025
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984758183102771
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