Journal article
Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
Dementia & neuropsychologia, Vol.5(1), pp.8-16
2011
DOI: 10.1590/S1980-57642011DN05010003
PMCID: PMC5619133
PMID: 29213714
Abstract
Several studies have demonstrated a wide cognitive variability among aged
individuals. One factor thought to be associated with this heterogeneity is
exposure to chronic stress throughout life. Animal and human evidence
demonstrates that glucocorticoids (GCs), the main class of stress hormones, are
strongly linked to memory performance whereby elevated GC levels are associated
with memory performance decline in both normal and pathological cognitive aging.
Accordingly, it is believed that GCs may increase the brain’s vulnerability to
the effects of internal and external insults, and thus may play a role in the
development of age-related cognitive disorders such as Alzheimer’s disease (AD).
The aim of this review article was to investigate the effects of GCs on normal
and pathological cognitive aging by showing how these hormones interact with
different brain structures involved in cognitive abilities, subsequently worsen
memory performance, and increase the risk for developing dementia.
Details
- Title: Subtitle
- Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
- Creators
- Juliana Nery de Souza-Talarico - PhD, Department of Medical-Surgical Nursing, School of Nursing, University of São Paulo, São Paulo SP, Brazil and Behavioral and Cognitive Neurology Unit, Department of Neurology, Faculty of Medicine, University of São Paulo, São Paulo SP, BrazilMarie-France Marin - MSc, Center for Studies on Human Stress, Mental Health Research Center Fernand-Seguin, Louis-H. Lafontaine Hospital, Université de Montreal, CanadaShireen Sindi - MSc, Department of Neurology and Neurosurgery, McGill University, Montreal, CanadaSonia J Lupien - PhD, Center for Studies on Human Stress, Mental Health Research Center Fernand-Seguin, Louis-H. Lafontaine Hospital, Université de Montreal, Canada
- Resource Type
- Journal article
- Publication Details
- Dementia & neuropsychologia, Vol.5(1), pp.8-16
- DOI
- 10.1590/S1980-57642011DN05010003
- PMID
- 29213714
- PMCID
- PMC5619133
- NLM abbreviation
- Dement Neuropsychol
- ISSN
- 1980-5764
- eISSN
- 1980-5764
- Publisher
- Associação de Neurologia Cognitiva e do Comportamento
- Language
- English
- Date published
- 2011
- Academic Unit
- Iowa Neuroscience Institute; Nursing
- Record Identifier
- 9984065374102771
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