Journal article
Effects of sympathetic activation on plasma renin activity in the developing rat
The Journal of pharmacology and experimental therapeutics, Vol.253(1), pp.152-157
1990
DOI: 10.1016/S0022-3565(25)12436-1
PMID: 2184217
Abstract
The present experiments studied the ontogeny of sympathetic control of the renin-angiotensin system by using pharmacological agents, which act at different levels of the sympathetic axis, to increase plasma renin activity (PRA) during the preweanling period in Sprague-Dawley rats. The selective beta-1 adrenoceptor agonist, prenalterol, produced age- and dose-dependent PRA increases. In 5- and 10-day-old animals, prenalterol treatment produced minimal stimulation of PRA and the dose-response curve was essentially flat. In contrast, greater PRA responses to increasing doses of prenalterol were found in 15- and 20-day-old animals. The PRA response to tyramine, which causes norepinephrine release from postganglionic sympathetic fibers, gradually increased between 5 and 20 postnatal days of age, first producing significant stimulation on day 15. Centrally mediated sympathetic activation with yohimbine also produced age-dependent stimulation of PRA that was comparable to the increases produced by tyramine between postnatal days 10 and 20. However, in contrast to tyramine, yohimbine produced a significant increase in PRA on postnatal day 5. The present results suggest that functional sympathetic control of the renin-angiotensin system matures during the second to third postnatal week in the Sprague-Dawley rat, and this may be related to the development of beta-1 adrenoceptors in the kidney that regulate renin release.
Details
- Title: Subtitle
- Effects of sympathetic activation on plasma renin activity in the developing rat
- Creators
- Robert F Kirby - Univ. Iowa, cardiovascular cent., dep. psychology, Iowa City IA 52242, United StatesAlan Kim Johnson - Univ. Iowa, cardiovascular cent., dep. psychology, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of pharmacology and experimental therapeutics, Vol.253(1), pp.152-157
- Publisher
- American Society for Pharmacology and Experimental Therapeutics
- DOI
- 10.1016/S0022-3565(25)12436-1
- PMID
- 2184217
- ISSN
- 0022-3565
- eISSN
- 1521-0103
- Language
- English
- Date published
- 1990
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; University College Courses; Health and Human Physiology
- Record Identifier
- 9984213262802771
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