Journal article
Effects of systemic administration of nicotine on capillaries in rat oral mucosa
Journal of oral pathology & medicine, Vol.18(4), pp.230-232
04/1989
DOI: 10.1111/j.1600-0714.1989.tb00768.x
PMID: 2769595
Abstract
This study examined the reaction of the local vasculature of the oral mucosa in 16 Sprague Dawley rats receiving systemic nicotine delivered (1.5 mg/kg/day) via subcutaneous minipumps for 24 h or 2wk. Control animals received saline. After treatment animals were killed and biopsies taken from palate, maxillary gingiva and buccal mucosa, frozen and cryostat sections incubated to demonstrate alkaline phosphatase, which is a capillary marker. The total length of the capillary fragments in the nicotine treated groups was significantly less than of the control group. There was also a decrease in capillary height in both of the nicotine groups when compared to the control animals. This study indicates that morphologic alterations occur in the microvasculature of the oral mucosa following systemic nicotine administration. This may have implications for the role of chronic tobacco use in the etiology of oral mucosal disease, including periodontal disease.
Details
- Title: Subtitle
- Effects of systemic administration of nicotine on capillaries in rat oral mucosa
- Creators
- G K Johnson - University of Nebraska Medical Center, College of Dentistry, Lincoln 68583-0740Y K FungC A Squier
- Resource Type
- Journal article
- Publication Details
- Journal of oral pathology & medicine, Vol.18(4), pp.230-232
- Publisher
- Denmark
- DOI
- 10.1111/j.1600-0714.1989.tb00768.x
- PMID
- 2769595
- ISSN
- 0904-2512
- eISSN
- 1600-0714
- Language
- English
- Date published
- 04/1989
- Academic Unit
- Oral Pathology, Radiology and Medicine; International Programs; Periodontics
- Record Identifier
- 9984065985802771
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