Journal article
Effects of tachycardia and ventricular filling pressure on stroke volume in the conscious dog
The American journal of physiology, Vol.220(2), pp.436-439
02/1971
DOI: 10.1152/ajplegacy.1971.220.2.436
PMID: 5540893
Abstract
The effects of tachycardia on the maximum stroke volume at the plateau of the ventricular output curve were studied in five chronically instrumented dogs. Tachycardia, produced by acute vagal blockage, increased the heart rate to an average of 199 zt 16 (SE) beats/min from an average resting rate of 97 ZIZ 12 beats/min. Resting ventricular output increased from an average of 103 & 12 to 128 & 28 ml/min per kg, whereas the stroke volume decreased as a linear function of the increase in heart rate. The plateau of the ventricular output curve increased from an average control level of 217 =t 25 to an average of 297 zt 35 ml/min per kg with the tachycardia produced by vagal blockage (P < 0.001). The average peak stroke-volume response at the peak of the ventricular output curve during acute vagal blockage was not significantly different from the average peak stroke-volume response attained during control ventricular output curves. The maximum stroke volume attained by acute loading was not influenced by the changes in heart rate encountered in this study.
Details
- Title: Subtitle
- Effects of tachycardia and ventricular filling pressure on stroke volume in the conscious dog
- Creators
- Vernon S Bishop - The University of Texas at San AntonioHubert L Stone - The University of Texas at San AntonioLawrence D Horwitz
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.220(2), pp.436-439
- DOI
- 10.1152/ajplegacy.1971.220.2.436
- PMID
- 5540893
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Language
- English
- Date published
- 02/1971
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656534502771
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