Effects of temporal properties on compound action potentials in response to amplitude-modulated electric pulse trains in guinea pigs

Fuh-Cherng Jeng; Paul J Abbas; Ning Hu; Charles A Miller; Kirill V Nourski; Barbara K Robinson

doi:10.1016/j.heares.2008.10.007

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Effects of temporal properties on compound action potentials in response to amplitude-modulated electric pulse trains in guinea pigs

Journal article

Peer reviewed

Effects of temporal properties on compound action potentials in response to amplitude-modulated electric pulse trains in guinea pigs

Fuh-Cherng Jeng, Paul J Abbas, Ning Hu, Charles A Miller, Kirill V Nourski and Barbara K Robinson

Hearing research, Vol.247(1), pp.47-59

2009

DOI: 10.1016/j.heares.2008.10.007

PMID: 19015019

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Abstract

The electrically evoked compound action potential (ECAP) of the auditory nerve in response to amplitude-modulated pulse trains varies over time, but the response amplitudes are not linearly proportional to the level of stimulus pulses. At least two mechanisms could contribute to the deviations of the ECAP response pattern from that of the stimulus envelope. The first mechanism is time-invariant or stationary that reflects the non-linear growth of response amplitude with changes in stimulus level that is evident in the response to single pulses. This can be considered a time-invariant or stationary effect. The second mechanism is time-variant or non-stationary and reflects neural refractoriness and adaptation. The purpose of this study was to characterize the auditory nerve responses to amplitude-modulated pulse trains and also to evaluate the extent to which the stationary and non-stationary effects may contribute to those responses. ECAP amplitudes were predicted from single-pulse growth functions of the auditory nerve to account for time-invariant effects. Linear regression was performed on the measured vs. predicted ECAP amplitudes to quantify the discrepancies between the two datasets, thereby separating the influence of non-linear growth from time-varying effects on ECAP amplitudes. The results demonstrated a bandpass function of the modulated response amplitudes, with a low-cutoff modulation frequency at 300 Hz and a high-cutoff modulation frequency at 800 Hz, depending on the carrier pulse rate. The relative contribution of the temporal effects on ECAP amplitudes is greatest at low stimulus levels and low modulation depths.

Cochlear implant

Amplitude modulation

Guinea pig

Compound action potential

Details

Title: Subtitle: Effects of temporal properties on compound action potentials in response to amplitude-modulated electric pulse trains in guinea pigs
Creators: Fuh-Cherng Jeng - School of Hearing, Speech and Language Sciences, Ohio University, Athens, OH 45701, USA
Paul J Abbas - Department of Communication Sciences and Disorders, Department of Otolaryngology-HNS, University of Iowa, USA
Ning Hu - Department of Communication Sciences and Disorders, Department of Otolaryngology-HNS, University of Iowa, USA
Charles A Miller - Department of Communication Sciences and Disorders, Department of Otolaryngology-HNS, University of Iowa, USA
Kirill V Nourski - Department of Communication Sciences and Disorders, Department of Otolaryngology-HNS, University of Iowa, USA
Barbara K Robinson - Department of Communication Sciences and Disorders, Department of Otolaryngology-HNS, University of Iowa, USA
Resource Type: Journal article
Publication Details: Hearing research, Vol.247(1), pp.47-59
DOI: 10.1016/j.heares.2008.10.007
PMID: 19015019
NLM abbreviation: Hear Res
ISSN: 0378-5955
eISSN: 1878-5891
Publisher: Elsevier B.V
Language: English
Date published: 2009
Academic Unit: Communication Sciences and Disorders; Iowa Neuroscience Institute; Biology; Neurosurgery; Otolaryngology
Record Identifier: 9984040000702771

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